Medication Regimen Complexity Index Prediction of Adverse Drug Reaction-Related Hospital Admissions.
Aged
Aged, 80 and over
Australia
/ epidemiology
Cohort Studies
Comorbidity
Drug-Related Side Effects and Adverse Reactions
/ epidemiology
Female
Hospitalization
/ statistics & numerical data
Hospitals
Humans
Male
Medical Records
Medication Therapy Management
Middle Aged
Polypharmacy
Prognosis
Retrospective Studies
Risk Factors
adverse drug reactions
hospital admission
medication regimen complexity
older patients
Journal
The Annals of pharmacotherapy
ISSN: 1542-6270
Titre abrégé: Ann Pharmacother
Pays: United States
ID NLM: 9203131
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
1
5
2020
medline:
1
1
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
The relationship between the medication regimen complexity index (MRCI) and adverse drug reaction (ADR)-related hospital admissions has not yet specifically been investigated. To evaluate the MRCI and compare with medication count for prediction of ADR-related hospital admissions in older patients. This was a retrospective analysis of a prospectively collected convenience sample of 768 unplanned medical admissions of Australians aged 65 years old and older. The sample consisted of 115 (15.0%) ADR-related unplanned hospital admissions and 653 (85.0%) non-ADR-related unplanned medical admissions. The MRCI score was calculated from the medical records and analyzed to predict ADR-related hospital admissions. The cohort had a median age of 81 years, 5 comorbidities, and 11 medications, with a slight majority of women. The MRCI score was not significantly different in patients who had ADR-related admissions compared with other medical admissions-38.5 versus 34.0, respectively; Wilcoxon Rank Sum test The MRCI score did not discriminate between ADR-related admissions and other medical admissions despite taking time to calculate with potential for inconsistent application. Medication count is more readily applicable with marginally greater relevance in this cohort; however, both measures do not appear to be useful when used alone for clinicians to identify patients at risk of ADRs.
Sections du résumé
BACKGROUND
The relationship between the medication regimen complexity index (MRCI) and adverse drug reaction (ADR)-related hospital admissions has not yet specifically been investigated.
OBJECTIVE
To evaluate the MRCI and compare with medication count for prediction of ADR-related hospital admissions in older patients.
METHODS
This was a retrospective analysis of a prospectively collected convenience sample of 768 unplanned medical admissions of Australians aged 65 years old and older. The sample consisted of 115 (15.0%) ADR-related unplanned hospital admissions and 653 (85.0%) non-ADR-related unplanned medical admissions. The MRCI score was calculated from the medical records and analyzed to predict ADR-related hospital admissions.
RESULTS
The cohort had a median age of 81 years, 5 comorbidities, and 11 medications, with a slight majority of women. The MRCI score was not significantly different in patients who had ADR-related admissions compared with other medical admissions-38.5 versus 34.0, respectively; Wilcoxon Rank Sum test
CONCLUSION AND RELEVANCE
The MRCI score did not discriminate between ADR-related admissions and other medical admissions despite taking time to calculate with potential for inconsistent application. Medication count is more readily applicable with marginally greater relevance in this cohort; however, both measures do not appear to be useful when used alone for clinicians to identify patients at risk of ADRs.
Identifiants
pubmed: 32349531
doi: 10.1177/1060028020919188
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM