Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: a case report.
Centrality
Focused ultrasound
Incident angle
Magnetic resonance guided
Mesial temporal lobe epilepsy
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
29 Apr 2020
29 Apr 2020
Historique:
received:
23
12
2019
accepted:
22
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
22
9
2020
Statut:
epublish
Résumé
We report the first case of transcranial magnetic resonance-guided focused ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE). The target was located 20 mm lateral from the midline and 15 mm above the skull base (left hippocampus). Despite the application of maximal energy, the ablation temperature did not exceed 50 °C, probably because of the low number of effective transducer elements with incident angles below 25 degrees. The skull density ratio was 0.56. Post-operative magnetic resonance imaging did not reveal any lesion and the patient remained almost seizure-free for up to 12 months. This preliminary case report suggests that MRgFUS may be effective for treating cases of MTLE. Therefore, the safety and feasibility of MRgFUS should be evaluated in future studies with larger numbers of participants and longer follow-up duration.
Sections du résumé
BACKGROUND
BACKGROUND
We report the first case of transcranial magnetic resonance-guided focused ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE).
CASE PRESENTATION
METHODS
The target was located 20 mm lateral from the midline and 15 mm above the skull base (left hippocampus). Despite the application of maximal energy, the ablation temperature did not exceed 50 °C, probably because of the low number of effective transducer elements with incident angles below 25 degrees. The skull density ratio was 0.56. Post-operative magnetic resonance imaging did not reveal any lesion and the patient remained almost seizure-free for up to 12 months.
CONCLUSIONS
CONCLUSIONS
This preliminary case report suggests that MRgFUS may be effective for treating cases of MTLE. Therefore, the safety and feasibility of MRgFUS should be evaluated in future studies with larger numbers of participants and longer follow-up duration.
Identifiants
pubmed: 32349706
doi: 10.1186/s12883-020-01744-x
pii: 10.1186/s12883-020-01744-x
pmc: PMC7189704
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
160Références
Neurosurg Focus. 2012 Jan;32(1):E2
pubmed: 22208895
Eur Radiol. 2019 Jul;29(7):3496-3505
pubmed: 30734849
J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1375-81
pubmed: 21653207
Lancet Neurol. 2018 Jan;17(1):54-63
pubmed: 29203153
N Engl J Med. 2001 Aug 2;345(5):311-8
pubmed: 11484687
Mov Disord. 2019 May;34(5):727-734
pubmed: 30759322
N Engl J Med. 2016 Aug 25;375(8):730-9
pubmed: 27557301
Neurosurg Focus. 2012 Jan;32(1):E1
pubmed: 22208894
Epilepsy Res. 2017 Nov;137:123-131
pubmed: 28939289
Acta Neurochir (Wien). 2010 Aug;152(8):1291-8
pubmed: 20361215
Ann Neurol. 2018 Jan;83(1):107-114
pubmed: 29265546
Lancet Neurol. 2013 May;12(5):462-8
pubmed: 23523144
Epilepsy Res. 2012 Nov;102(1-2):34-44
pubmed: 22591753
J Neurosurg. 2016 Dec;125(6):1557-1564
pubmed: 26871207
J Neurosurg. 2016 Feb;124(2):411-6
pubmed: 26361280
Psychiatr Clin North Am. 2018 Sep;41(3):505-514
pubmed: 30098661
Epilepsia. 2018 Jun;59(6):1198-1207
pubmed: 29600809
J Clin Neurosci. 2017 Apr;38:1-7
pubmed: 28024732
J Neurosurg. 2019 Jun 14;:1-8
pubmed: 31200385
JAMA Neurol. 2017 Dec 1;74(12):1412-1418
pubmed: 29084313
Front Cell Neurosci. 2013 Oct 01;7:167
pubmed: 24098270
J Neurosurg. 2018 Sep 21;131(2):384-386
pubmed: 30239322
Neurol Med Chir (Tokyo). 2012;52(12):892-8
pubmed: 23269044
AJNR Am J Neuroradiol. 1999 Feb;20(2):213-6
pubmed: 10094340
Mol Psychiatry. 2015 Oct;20(10):1205-11
pubmed: 25421403