Virologic and Immunologic Features of Simian Immunodeficiency Virus Control Post-ART Interruption in Rhesus Macaques.

Animals Anti-Retroviral Agents / pharmacology CD4-CD8 Ratio CD8-Positive T-Lymphocytes / immunology DNA, Viral / blood Macaca mulatta Simian Acquired Immunodeficiency Syndrome / blood Simian Immunodeficiency Virus / immunology Th17 Cells / immunology Time Factors
HIV-1 PTC SIV Th17 analytic treatment interruption posttreatment controller viral rebound

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
01 07 2020
Historique:
received: 26 02 2020
accepted: 17 04 2020
pubmed: 1 5 2020
medline: 20 11 2020
entrez: 1 5 2020
Statut: epublish

Résumé

Antiretroviral therapy (ART) cannot eradicate human immunodeficiency virus (HIV) and a rapid rebound of virus replication follows analytical treatment interruption (ATI) in the vast majority of HIV-infected individuals. Sustained control of HIV replication without ART has been documented in a subset of individuals, defined as posttreatment controllers (PTCs). The key determinants of post-ART viral control remain largely unclear. Here, we identified 7 SIV

Identifiants

DOI: 10.1128/JVI.00338-20 PMID: 32350073 PMC: PMC7343203
pubmed: 32350073
pii: JVI.00338-20
doi: 10.1128/JVI.00338-20
pmc: PMC7343203
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0
DNA, Viral 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116379
Pays : United States
Organisme : NIH HHS
ID : U42 OD011023
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Zachary Strongin (Z)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Luca Micci (L)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Rémi Fromentin (R)

Centre de recherche du CHUM, Montreal, Quebec, Canada.
Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.

Justin Harper (J)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Julia McBrien (J)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Emily Ryan (E)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Neeta Shenvi (N)

Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Kirk Easley (K)

Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Nicolas Chomont (N)

Centre de recherche du CHUM, Montreal, Quebec, Canada.
Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.

Guido Silvestri (G)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Mirko Paiardini (M)

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA mirko.paiardini@emory.edu.
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Phénomènes du système immunitaire › Rapport CD4-CD8 › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN viral › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Maladies de l'animal › Maladies des primates › Maladies des singes › Syndrome d'immunodéficience acquise du singe › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Rétrovirus simiens › Virus de l'immunodéficience simienne › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Virologic and Immunologic Features of Simian...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Virologic and Immunologic Features of Simian...