Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.
Adenosine Triphosphate
/ metabolism
Energy Metabolism
/ drug effects
Flagella
/ drug effects
Glycolysis
/ drug effects
Membrane Potential, Mitochondrial
/ drug effects
Metabolome
/ drug effects
Microbodies
/ drug effects
Mitochondria
/ drug effects
Models, Molecular
Proline
/ metabolism
Proteome
/ metabolism
Proton-Translocating ATPases
/ metabolism
Protozoan Proteins
/ metabolism
Pyruvic Acid
/ metabolism
Suramin
/ pharmacology
Trypanosoma brucei brucei
/ metabolism
Trypanosoma brucei
differentiation
drug action
drug mechanisms
energy homeostasis
glycosomes
metabolomics
parasite metabolism
polypharmacology
proteomics
sleeping sickness
suramin
trypanosome
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
12 06 2020
12 06 2020
Historique:
received:
09
01
2020
revised:
21
04
2020
pubmed:
2
5
2020
medline:
31
12
2020
entrez:
2
5
2020
Statut:
ppublish
Résumé
Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into the causative agent, the protozoan parasite
Identifiants
pubmed: 32354742
pii: S0021-9258(17)49420-8
doi: 10.1074/jbc.RA120.012355
pmc: PMC7294092
doi:
Substances chimiques
Proteome
0
Protozoan Proteins
0
Suramin
6032D45BEM
Pyruvic Acid
8558G7RUTR
Adenosine Triphosphate
8L70Q75FXE
Proline
9DLQ4CIU6V
Proton-Translocating ATPases
EC 3.6.3.14
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8331-8347Subventions
Organisme : Medical Research Council
ID : MR/N010558/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203134/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104111/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P009018/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N01037X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204697/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2020 Zoltner et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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