Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport.
Amino Acid Sequence
Calcium
/ chemistry
Crystallography, X-Ray
Glycoproteins
/ metabolism
Mannose-Binding Lectins
/ chemistry
Membrane Proteins
/ chemistry
Models, Molecular
Oligosaccharides
/ chemistry
Protein Binding
Protein Conformation
Protein Conformation, alpha-Helical
/ genetics
Recombinant Proteins
/ chemistry
Vesicular Transport Proteins
/ chemistry
ERGIC-53
MCFD2
cargo receptor
conformational polymorphism
crystal packing
glycoprotein transport
intracellular lectin
Journal
Acta crystallographica. Section F, Structural biology communications
ISSN: 2053-230X
Titre abrégé: Acta Crystallogr F Struct Biol Commun
Pays: United States
ID NLM: 101620319
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
received:
28
02
2020
accepted:
19
04
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
9
2
2021
Statut:
ppublish
Résumé
The transmembrane intracellular lectin ER-Golgi intermediate compartment protein 53 (ERGIC-53) and the soluble EF-hand multiple coagulation factor deficiency protein 2 (MCFD2) form a complex that functions as a cargo receptor, trafficking various glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53
Identifiants
pubmed: 32356523
pii: S2053230X20005452
doi: 10.1107/S2053230X20005452
pmc: PMC7193514
doi:
Substances chimiques
Glycoproteins
0
LMAN1 protein, human
0
MCFD2 protein, human
0
Mannose-Binding Lectins
0
Membrane Proteins
0
Oligosaccharides
0
Recombinant Proteins
0
Vesicular Transport Proteins
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-221Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP19H03361
Organisme : National Institutes of Natural Sciences
ID : 19-315
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