Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine.
Animals
Astrocytes
/ drug effects
Depression
/ drug therapy
Disease Models, Animal
Glutamic Acid
/ metabolism
Male
Mice, Inbred C57BL
Neurons
/ drug effects
Neurotransmitter Agents
/ metabolism
Phenethylamines
/ metabolism
Pyridines
/ metabolism
Stress, Psychological
/ metabolism
Sucrose
/ metabolism
(13)C Nuclear magnetic resonance spectroscopy
GABA
Glutamate
Glutamine
Neuron-Glia interaction
Neurotransmission
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
09
12
2019
revised:
05
04
2020
accepted:
24
04
2020
pubmed:
4
5
2020
medline:
10
7
2021
entrez:
4
5
2020
Statut:
ppublish
Résumé
Major depressive disorder is the leading cause of disability and suicidality worldwide. Here, we evaluated neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three weeks to induce depression. Further, the efficacy of Lanicemine, a low trapping NMDA receptor antagonist, on behavioral and neurometabolic measures in CUMS mice was evaluated. The PFC neuronal and astroglial metabolic activity was evaluated by Proton Observed Carbon Edited (POCE) MR spectroscopy together with an infusion of [1,6-
Identifiants
pubmed: 32360130
pii: S0197-0186(20)30141-8
doi: 10.1016/j.neuint.2020.104750
pii:
doi:
Substances chimiques
AZD6765
0
Neurotransmitter Agents
0
Phenethylamines
0
Pyridines
0
Glutamic Acid
3KX376GY7L
Sucrose
57-50-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104750Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK108283
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA021984
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.