Chemical Profiling and Cholinesterase Inhibitory Activity of Five
Acetylcholinesterase
/ chemistry
Alkaloids
/ chemistry
Amaryllidaceae
/ chemistry
Binding Sites
Cholinesterase Inhibitors
/ chemistry
Drug Discovery
Ecuador
Gas Chromatography-Mass Spectrometry
Models, Molecular
Molecular Conformation
Molecular Structure
Phytochemicals
/ chemistry
Plant Extracts
/ chemistry
Protein Binding
Structure-Activity Relationship
Amaryllidaceae
GC-MS
Phaedranassa
alkaloids
cholinesterases
molecular docking
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
30 Apr 2020
30 Apr 2020
Historique:
received:
03
03
2020
revised:
13
04
2020
accepted:
21
04
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
10
2
2021
Statut:
epublish
Résumé
It is estimated that 50 million people in the world live with dementia, 60-70% of whom suffer from Alzheimer's disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level. The Amaryllidaceae plant family contains an exclusive, large, and still understudied alkaloid group characterized by a singular skeleton arrangement and a broad spectrum of biological activities. The chemistry and biodiversity of Ecuadorian representatives of the
Identifiants
pubmed: 32365796
pii: molecules25092092
doi: 10.3390/molecules25092092
pmc: PMC7248819
pii:
doi:
Substances chimiques
Alkaloids
0
Cholinesterase Inhibitors
0
Phytochemicals
0
Plant Extracts
0
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CYTED Ciencia y Tecnología para el Desarrollo
ID : Red BIFRENES 416RT0511
Références
J Nat Prod. 2016 Mar 25;79(3):629-61
pubmed: 26852623
Molecules. 2018 Jun 26;23(7):
pubmed: 29949847
Nat Chem. 2016 Jun;8(6):531-41
pubmed: 27219696
FEBS Lett. 1999 Dec 17;463(3):321-6
pubmed: 10606746
Molecules. 2017 Dec 09;22(12):
pubmed: 29232852
Biol Psychiatry. 2001 Feb 1;49(3):279-88
pubmed: 11230879
Drug Discov Today. 2000 Jul;5(7):294-300
pubmed: 10856912
J Pharmacol Exp Ther. 1996 May;277(2):728-38
pubmed: 8627552
J Med Chem. 2006 Jun 1;49(11):3315-21
pubmed: 16722650
J Pharm Pharmacol. 2013 Dec;65(12):1701-25
pubmed: 24236981
J Biol Chem. 2003 Oct 17;278(42):41141-7
pubmed: 12869558
J Comput Chem. 2009 Dec;30(16):2785-91
pubmed: 19399780
Nat Prod Commun. 2014 Aug;9(8):1081-6
pubmed: 25233578
Biochem J. 2013 Aug 1;453(3):393-9
pubmed: 23679855
Alkaloids Chem Biol. 2006;63:87-179
pubmed: 17133715
Phytochem Anal. 2018 Mar;29(2):217-227
pubmed: 29044771
J Hered. 2012 Jul;103(4):557-69
pubmed: 22563126
Life Sci. 2002 Oct 11;71(21):2521-9
pubmed: 12270757
Fitoterapia. 2014 Jan;92:163-7
pubmed: 24257197
Science. 1991 Aug 23;253(5022):872-9
pubmed: 1678899
Biochem Pharmacol. 1961 Jul;7:88-95
pubmed: 13726518
Bioorg Med Chem Lett. 2015 Nov 1;25(21):4802-4807
pubmed: 26254944
Physiol Rev. 2001 Apr;81(2):741-66
pubmed: 11274343