IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
Animals
Cell Adhesion
/ drug effects
Cells, Cultured
DNA, Neoplasm
/ drug effects
Disease Progression
Extracellular Traps
/ drug effects
Female
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Inflammation Mediators
/ pharmacology
Interleukins
/ genetics
Mice
Mice, Inbred C57BL
Mice, SCID
Neoplasm Transplantation
/ immunology
Neutrophils
/ pathology
Triple Negative Breast Neoplasms
/ genetics
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
21
12
2018
revised:
23
05
2019
accepted:
29
04
2020
pubmed:
6
5
2020
medline:
5
1
2021
entrez:
6
5
2020
Statut:
ppublish
Résumé
IL26 is a unique amphipathic member of the IL10 family of cytokines that participates in inflammatory signaling through a canonical receptor pathway. It also directly binds DNA to facilitate cellular transduction and intracellular inflammatory signaling. Although IL26 has almost no described role in cancer, our
Identifiants
pubmed: 32366475
pii: 0008-5472.CAN-18-3825
doi: 10.1158/0008-5472.CAN-18-3825
pmc: PMC7415539
mid: NIHMS1591951
doi:
Substances chimiques
DNA, Neoplasm
0
IL26 protein, human
0
Inflammation Mediators
0
Interleukins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3088-3100Subventions
Organisme : NCI NIH HHS
ID : K12 CA100639
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA238217
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009111
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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