Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery.
Administration, Oral
Animals
Biological Availability
Caprylates
/ chemistry
Dioctyl Sulfosuccinic Acid
/ chemistry
Drug Carriers
/ chemistry
Drug Delivery Systems
/ methods
Exenatide
/ chemistry
Glucagon-Like Peptide 1
/ analogs & derivatives
Glycerides
/ chemistry
Humans
Hydrophobic and Hydrophilic Interactions
Lipids
/ chemistry
Male
Nanoparticles
/ chemistry
Polyethylene Glycols
/ chemistry
Propylene Glycol
/ chemistry
Rats
Rats, Sprague-Dawley
Solubility
Surface-Active Agents
/ chemistry
Tacrine
/ chemistry
Exenatide
GLP-1 analogue
HIP
Hydrophobic ion pairing
Nanocarriers
Oral bioavailability
Oral peptide drug delivery
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
04
03
2020
revised:
24
04
2020
accepted:
25
04
2020
pubmed:
7
5
2020
medline:
7
2
2021
entrez:
7
5
2020
Statut:
ppublish
Résumé
The lipophilic character of peptides can be tremendously improved by hydrophobic ion pairing (HIP) with counterions to be efficiently incorporated into lipid-based nanocarriers (NCs). Herein, HIPs of exenatide with the cationic surfactant tetraheptylammonium bromide (THA) and the anionic surfactant sodium docusate (DOC) were formed to increase its lipophilicity. These HIPs were incorporated into lipid based NCs comprising 41% Capmul MCM, 15% Captex 355, 40% Cremophor RH and 4% propylene glycol. Exenatide-THA NCs showed a log D
Identifiants
pubmed: 32371152
pii: S0939-6411(20)30112-0
doi: 10.1016/j.ejpb.2020.04.025
pii:
doi:
Substances chimiques
Caprylates
0
Drug Carriers
0
Glycerides
0
Lipids
0
Surface-Active Agents
0
Dioctyl Sulfosuccinic Acid
10041-19-7
cremophor
39279-69-1
Polyethylene Glycols
3WJQ0SDW1A
Tacrine
4VX7YNB537
Propylene Glycol
6DC9Q167V3
Glucagon-Like Peptide 1
89750-14-1
Exenatide
9P1872D4OL
monooctanoin
VFU0OU98LO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-17Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.