Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.

Animals Antibodies, Neutralizing / pharmacology Apoptosis / drug effects Carcinoma, Pancreatic Ductal / complications Cells, Cultured Diabetes Mellitus / etiology Disease Models, Animal Disease Progression Gene Deletion Insulin-Secreting Cells / metabolism Mice Mice, Inbred C57BL Mice, Transgenic Pancreatic Neoplasms / complications Prognosis Receptor, Transforming Growth Factor-beta Type II / genetics Signal Transduction / drug effects Smad4 Protein / genetics Transforming Growth Factor beta1 / immunology

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
06 2020
Historique:
received: 07 10 2019
revised: 21 04 2020
accepted: 23 04 2020
entrez: 7 5 2020
pubmed: 7 5 2020
medline: 8 7 2021
Statut: epublish

Résumé

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that remains incurable because of late diagnosis, which renders any therapeutic intervention challenging. Most PDAC patients develop de novo diabetes, which exacerbates their morbidity and mortality. How PDAC triggers diabetes is still unfolding. Using a mouse model of Kras

Identifiants

DOI: 10.26508/lsa.201900573 PMID: 32371554 PMC: PMC7211975
pubmed: 32371554
pii: 3/6/e201900573
doi: 10.26508/lsa.201900573
pmc: PMC7211975
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
Smad4 Protein 0
Smad4 protein, mouse 0
Tgfb1 protein, mouse 0
Transforming Growth Factor beta1 0
Receptor, Transforming Growth Factor-beta Type II EC 2.7.11.30
Tgfbr2 protein, mouse EC 2.7.11.30

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR059070
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA210911
Pays : United States

Informations de copyright

© 2020 Parajuli et al.

Références

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Auteurs

Parash Parajuli (P)

Cellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.

Thien Ly Nguyen (TL)

Cellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.

Céline Prunier (C)

Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, France.

Mohammed S Razzaque (MS)

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.
ORCID: 0000-0003-1115-4550

Keli Xu (K)

Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
ORCID: 0000-0001-5535-1076

Azeddine Atfi (A)

Cellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA azeddine.atfi@inserm.fr.
Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, France.
ORCID: 0000-0002-9986-3572

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Cellules › Cellules cultivées › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Diagnostic › Pronostic › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs TGF-bêta › Récepteur de type II du facteur de croissance transformant bêta › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines Smad › Protéine Smad-4 › Pancreatic cancer triggers diabetes through...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-1 › Pancreatic cancer triggers diabetes through...