Calcitonin gene-related peptide inhibits angiotensin II-induced NADPH oxidase-dependent ROS via the Src/STAT3 signalling pathway.
Angiotensin II
/ pharmacology
Animals
Antioxidants
/ metabolism
Calcitonin
/ metabolism
Calcitonin Gene-Related Peptide
/ metabolism
Humans
Male
Mice
Mice, Inbred C57BL
Muscle, Smooth, Vascular
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
NADPH Oxidases
/ metabolism
Oxidation-Reduction
/ drug effects
Oxidative Stress
/ drug effects
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
/ metabolism
STAT3 Transcription Factor
/ metabolism
Signal Transduction
/ drug effects
src-Family Kinases
/ metabolism
Ang II
CGRP
ROS
STAT3
Src
VSMCs
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
30
07
2019
revised:
18
03
2020
accepted:
26
03
2020
pubmed:
7
5
2020
medline:
30
4
2021
entrez:
7
5
2020
Statut:
ppublish
Résumé
We had previously demonstrated that the calcitonin gene-related peptide (CGRP) suppresses the oxidative stress and vascular smooth muscle cell (VSMC) proliferation induced by vascular injury. A recent study also indicated that CGRP protects against the onset and development of angiotensin II (Ang II)-induced hypertension, vascular hypertrophy and oxidative stress. However, the mechanism behind the effects of CGRP on Ang II-induced oxidative stress is unclear. CGRP significantly suppressed the level of reactive oxygen species (ROS) generated by NADPH oxidase in Ang II-induced VSMCs. The Ang II-stimulated activation of both Src and the downstream transcription factor, STAT3, was abrogated by CGRP. However, the antioxidative effect of CGRP was lost following the expression of constitutively activated Src or STAT3. Pre-treatment with H-89 or CGRP
Identifiants
pubmed: 32372557
doi: 10.1111/jcmm.15288
pmc: PMC7294141
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Angiotensin II
11128-99-7
Calcitonin
9007-12-9
NADPH Oxidases
EC 1.6.3.-
src-Family Kinases
EC 2.7.10.2
Calcitonin Gene-Related Peptide
JHB2QIZ69Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6426-6437Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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