The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study.
Aged
Alzheimer Disease
/ diagnostic imaging
Amyloid beta-Peptides
/ metabolism
Cognitive Dysfunction
/ diagnostic imaging
Disease Progression
Female
Humans
Image Interpretation, Computer-Assisted
/ methods
Inflammation
/ diagnostic imaging
Longitudinal Studies
Male
Neurofibrillary Tangles
/ pathology
Positron-Emission Tomography
Prodromal Symptoms
tau Proteins
/ metabolism
Alzheimer
Flortaucipir
MCI
Microglia
Neuroinflammation
PET
PK11195
PiB
Tau
β-amyloid
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
06 May 2020
06 May 2020
Historique:
received:
20
10
2019
accepted:
17
04
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
19
3
2021
Statut:
epublish
Résumé
The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels of inflammation and the loads of aggregated β-amyloid and tau at baseline and again after 2 years in prodromal Alzheimer's disease. Forty-three subjects with mild cognitive impairment (MCI) had serial Those MCI subjects with high Our baseline and 2-year imaging findings are compatible with a biphasic trajectory of inflammation in Alzheimer's disease: MCI cases with low baseline but subsequently rising β-amyloid load show correlated levels of microglial activation which then later decline when the β-amyloid load approaches AD levels. Later, as tau tangles form in β-amyloid positive MCI cases with prodromal AD, the rising tau load is associated with higher levels of inflammation.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels of inflammation and the loads of aggregated β-amyloid and tau at baseline and again after 2 years in prodromal Alzheimer's disease.
METHODS
METHODS
Forty-three subjects with mild cognitive impairment (MCI) had serial
RESULTS
RESULTS
Those MCI subjects with high
CONCLUSIONS
CONCLUSIONS
Our baseline and 2-year imaging findings are compatible with a biphasic trajectory of inflammation in Alzheimer's disease: MCI cases with low baseline but subsequently rising β-amyloid load show correlated levels of microglial activation which then later decline when the β-amyloid load approaches AD levels. Later, as tau tangles form in β-amyloid positive MCI cases with prodromal AD, the rising tau load is associated with higher levels of inflammation.
Identifiants
pubmed: 32375809
doi: 10.1186/s12974-020-01820-6
pii: 10.1186/s12974-020-01820-6
pmc: PMC7203856
doi:
Substances chimiques
Amyloid beta-Peptides
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151Références
Neurology. 2003 May 13;60(9):1495-500
pubmed: 12743238
Alzheimers Dement. 2015 Aug;11(8):975-85
pubmed: 26141264
Trends Neurosci. 1996 Aug;19(8):312-8
pubmed: 8843599
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
Med Image Comput Comput Assist Interv. 2007;10(Pt 1):409-16
pubmed: 18051085
J Neuroimaging. 2019 Jul;29(4):499-505
pubmed: 31074062
J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205
pubmed: 8126267
Med Image Comput Comput Assist Interv. 2006;9(Pt 2):823-30
pubmed: 17354849
Alzheimers Dement. 2016 Jun;12(6):719-32
pubmed: 27179961
Brain. 2017 Mar 1;140(3):792-803
pubmed: 28122877
Neuroimage. 1996 Dec;4(3 Pt 1):153-8
pubmed: 9345505
Brain Pathol. 2020 Jan;30(1):151-164
pubmed: 31276244
Neurobiol Aging. 2004 May-Jun;25(5):663-74
pubmed: 15172746
Neuroimage. 2011 Jan 1;54(1):313-27
pubmed: 20656036
Brain. 2016 Apr;139(Pt 4):1252-64
pubmed: 26984188
Hum Brain Mapp. 2003 Aug;19(4):224-47
pubmed: 12874777
Brain. 2016 Jul;139(Pt 7):2039-49
pubmed: 27190023
Brain. 2015 Jul;138(Pt 7):2020-33
pubmed: 25953778
Lancet Neurol. 2013 Apr;12(4):357-67
pubmed: 23477989
Neurobiol Dis. 2018 Sep;117:211-216
pubmed: 29902557
J Nucl Med. 2007 Jan;48(1):158-67
pubmed: 17204713
Arch Neurol. 1999 Mar;56(3):303-8
pubmed: 10190820
Am J Pathol. 2016 Feb;186(2):375-84
pubmed: 26687817
Brain. 2017 Jul 1;140(7):2002-2011
pubmed: 28575151
Neurosci Res. 2014 Feb;79:1-12
pubmed: 24144733
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Front Neuroinform. 2016 Aug 11;10:35
pubmed: 27563289
Neuroimage. 2013 Nov 15;82:393-402
pubmed: 23719155
Neurology. 2013 Mar 5;80(10):890-6
pubmed: 23446680
Am J Pathol. 2011 Sep;179(3):1373-84
pubmed: 21777559
Brain. 2017 Mar 1;140(3):748-763
pubmed: 28077397
Neuron. 2007 Feb 1;53(3):337-51
pubmed: 17270732
Brain. 2015 Jun;138(Pt 6):1738-55
pubmed: 25833819
Neuroimage. 2014 May 1;91:412-9
pubmed: 24412399