Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors.

Adrenergic alpha-1 Receptor Agonists / pharmacology Adrenergic alpha-1 Receptor Antagonists / pharmacology Adult Aged Aged, 80 and over Colon / cytology Female Gastrointestinal Transit / drug effects Humans Male Middle Aged Muscle Contraction / drug effects Myocytes, Smooth Muscle / drug effects Norepinephrine / pharmacology Receptor, Platelet-Derived Growth Factor alpha / metabolism Receptors, Adrenergic, alpha-1 / metabolism
Colonic Motility PDGFRα(+) Cells SIP Syncytium Sympathetic Nervous System α1 Adrenoceptor

Journal

Cellular and molecular gastroenterology and hepatology
ISSN: 2352-345X
Titre abrégé: Cell Mol Gastroenterol Hepatol
Pays: United States
ID NLM: 101648302

Informations de publication

Date de publication:
2020
Historique:
received: 12 12 2019
revised: 24 04 2020
accepted: 27 04 2020
pubmed: 8 5 2020
medline: 8 9 2021
entrez: 8 5 2020
Statut: ppublish

Résumé

Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α Isometric tension recording, intracellular recording, and Ca Exogenous or endogenous norepinephrine released from nerve fibers inhibited colonic contractions through binding to α1A ARs or enhanced colonic contractions by acting on α1D ARs. Inhibitory responses were blocked by apamin, an antagonist of SK channels. Phenylephrine, α1 AR agonists, or norepinephrine increased intracellular [Ca Human colonic contractions are inhibited by α1A ARs expressed in PDGFRα

Sections du résumé

BACKGROUND & AIMS
Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α
METHODS
Isometric tension recording, intracellular recording, and Ca
RESULTS
Exogenous or endogenous norepinephrine released from nerve fibers inhibited colonic contractions through binding to α1A ARs or enhanced colonic contractions by acting on α1D ARs. Inhibitory responses were blocked by apamin, an antagonist of SK channels. Phenylephrine, α1 AR agonists, or norepinephrine increased intracellular [Ca
CONCLUSIONS
Human colonic contractions are inhibited by α1A ARs expressed in PDGFRα

Identifiants

DOI: 10.1016/j.jcmgh.2020.04.015 PMID: 32376421 PMC: PMC7474159
pubmed: 32376421
pii: S2352-345X(20)30065-5
doi: 10.1016/j.jcmgh.2020.04.015
pmc: PMC7474159
pii:
doi:

Substances chimiques

ADRA1A protein, human 0
ADRA1D protein, human 0
Adrenergic alpha-1 Receptor Agonists 0
Adrenergic alpha-1 Receptor Antagonists 0
Receptors, Adrenergic, alpha-1 0
Receptor, Platelet-Derived Growth Factor alpha EC 2.7.10.1
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article Research Support, N.I.H., Extramural Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

658-671.e1

Subventions

Organisme : NIGMS NIH HHS
ID : P30 GM110767
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091336
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Masaaki Kurahashi (M)

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada. Electronic address: mkurahashi@med.unr.edu.

Yoshihiko Kito (Y)

Department of Pharmacology, Saga University, Saga, Japan.

Masayasu Hara (M)

Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Hiromitsu Takeyama (H)

Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Kenton M Sanders (KM)

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada.

Hikaru Hashitani (H)

Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes alpha-adrénergiques › Agonistes des récepteurs alpha-1 adrénergiques › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes alpha-adrénergiques › Antagonistes des récepteurs alpha-1 adrénergiques › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Motilité gastrointestinale › Transit gastrointestinal › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance dérivés des plaquettes › Récepteur au PDGF alpha › Norepinephrine Has Dual Effects on Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs adrénergiques › Récepteurs alpha-adrénergiques › Récepteurs alpha-1 adrénergiques › Norepinephrine Has Dual Effects on Human...