Pharmacologic fibroblast reprogramming into photoreceptors restores vision.
Animals
Axin Protein
/ metabolism
Basic Helix-Loop-Helix Transcription Factors
/ metabolism
Cellular Reprogramming
/ drug effects
Disease Models, Animal
Fibroblasts
/ cytology
Flow Cytometry
Mice
Mitochondria
/ drug effects
NF-kappa B
/ metabolism
Protein Transport
/ drug effects
Reactive Oxygen Species
/ metabolism
Retinal Degeneration
/ pathology
Retinal Rod Photoreceptor Cells
/ cytology
Signal Transduction
/ drug effects
Vision, Ocular
/ drug effects
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
23
10
2018
accepted:
10
02
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
13
6
2020
Statut:
ppublish
Résumé
Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision
Identifiants
pubmed: 32376950
doi: 10.1038/s41586-020-2201-4
pii: 10.1038/s41586-020-2201-4
pmc: PMC7469946
mid: NIHMS1616072
doi:
Substances chimiques
Ascl1 protein, mouse
0
Axin Protein
0
Axin2 protein, mouse
0
Basic Helix-Loop-Helix Transcription Factors
0
NF-kappa B
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-88Subventions
Organisme : NEI NIH HHS
ID : R01 EY028216
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025717
Pays : United States
Organisme : NEI NIH HHS
ID : K08 EY021171
Pays : United States
Organisme : NEI NIH HHS
ID : R44 EY025905
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025667
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
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