Discovery and structure-activity relationships study of positive allosteric modulators of the M
Allosteric Regulation
Amines
/ chemistry
Animals
CHO Cells
Central Nervous System
/ drug effects
Cricetulus
Drug Evaluation, Preclinical
High-Throughput Screening Assays
Humans
Muscarinic Agonists
/ chemical synthesis
Neuroprotective Agents
/ chemical synthesis
Piperidines
/ chemistry
Pyrrolidines
/ chemistry
Rats
Receptors, Muscarinic
/ metabolism
Stereoisomerism
Structure-Activity Relationship
Thiazoles
/ chemical synthesis
Allosteric enhancers
M(3) muscarinic acetylcholine receptor
Positive allosteric modulators
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
05
03
2020
revised:
22
04
2020
accepted:
23
04
2020
pubmed:
11
5
2020
medline:
24
3
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
The M
Identifiants
pubmed: 32386953
pii: S0968-0896(20)30357-6
doi: 10.1016/j.bmc.2020.115531
pii:
doi:
Substances chimiques
Amines
0
Muscarinic Agonists
0
Neuroprotective Agents
0
Piperidines
0
Pyrrolidines
0
Receptors, Muscarinic
0
Thiazoles
0
2-aminothiazole
5K8WKN668K
piperidine
67I85E138Y
pyrrolidine
LJU5627FYV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115531Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.