Form-Vessel Classification of Cholangioscopy Findings to Diagnose Biliary Tract Carcinoma's Superficial Spread.
bile duct cancer
biopsy
cholangioscope
genetic mutation
tumor spread
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 May 2020
07 May 2020
Historique:
received:
08
04
2020
revised:
29
04
2020
accepted:
05
05
2020
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
11
2
2021
Statut:
epublish
Résumé
We aimed to evaluate a newly developed peroral cholangioscopy (POCS) classification system by comparing classified lesions with histological and genetic findings. We analyzed 30 biopsied specimens from 11 patients with biliary tract cancer (BTC) who underwent POCS. An original classification of POCS findings was made based on the biliary surface's form (F factor, 4 grades) and vessel structure (V-factor, 3 grades). Findings were then compared with those of corresponding biopsy specimens analyzed histologically and by next-generation sequencing to identify somatic mutations. In addition, the histology of postoperative surgical stumps and preoperative POCS findings were compared. Histological malignancy rate in biopsied specimens increased with increasing F- and V-factor scores (F1, 0%; F1, 25%; F3, 50%; F4, 62.5%;
Identifiants
pubmed: 32392821
pii: ijms21093311
doi: 10.3390/ijms21093311
pmc: PMC7246671
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18K07999
Organisme : Japan Society for the Promotion of Science
ID : JP15K09044
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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