RAS protein
bedside-to-bench analysis
colon cancer
exome sequencing
oncogene
personalized medicine
protein structure
structural biology
switch II domain
tandem duplication
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
13
09
2019
revised:
06
05
2020
pubmed:
13
5
2020
medline:
14
1
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
The oncogene RAS is one of the most widely studied proteins in cancer biology, and mutant active RAS is a driver in many types of solid tumors and hematological malignancies. Yet the biological effects of different
Identifiants
pubmed: 32393580
pii: S0021-9258(17)48957-5
doi: 10.1074/jbc.RA119.011080
pmc: PMC7363148
doi:
Substances chimiques
KRAS protein, human
0
MAS1 protein, human
0
Membrane Proteins
0
Proto-Oncogene Mas
0
raf Kinases
EC 2.7.11.1
GTP Phosphohydrolases
EC 3.6.1.-
NRAS protein, human
EC 3.6.1.-
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Banques de données
PDB
['6OB2', '1HE8', '4G0N', '3CON', '6MBT']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
9335-9348Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000114
Pays : United States
Organisme : NIH HHS
ID : S10 OD021527
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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