AURKA destruction is decoupled from its activity at mitotic exit but is essential to suppress interphase activity.
Aurora A kinase
Cdh1
FZR1
Mitochondria
Mitosis
TPX2
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
received:
19
12
2019
accepted:
19
04
2020
pubmed:
13
5
2020
medline:
22
6
2021
entrez:
13
5
2020
Statut:
epublish
Résumé
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks at mitosis, before AURKA is degraded during and after mitotic exit in a process strictly dependent on the APC/C coactivator FZR1. We used FZR1 knockout cells (FZR1
Identifiants
pubmed: 32393600
pii: jcs.243071
doi: 10.1242/jcs.243071
pmc: PMC7328152
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Ubiquitin-Protein Ligase Complexes
EC 2.3.2.23
Anaphase-Promoting Complex-Cyclosome
EC 2.3.2.27
Aurora Kinase A
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R004137/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M01102X/1
Pays : United Kingdom
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
Références
PLoS Comput Biol. 2011 Oct;7(10):e1002212
pubmed: 21998575
Mol Biol Cell. 2012 Jul;23(14):2658-70
pubmed: 22621899
J Cell Biol. 2012 Apr 2;197(1):19-26
pubmed: 22451695
J Biol Chem. 2012 Jan 6;287(2):1150-7
pubmed: 22094468
EMBO Rep. 2013 Sep;14(9):829-36
pubmed: 23887685
Sci Rep. 2016 Apr 15;6:24356
pubmed: 27079678
J Cell Sci. 2011 Jan 1;124(Pt 1):113-22
pubmed: 21147853
EMBO Rep. 2002 May;3(5):457-62
pubmed: 11964384
Curr Biol. 2008 Nov 11;18(21):1649-58
pubmed: 18976910
Cancer Cell. 2009 Jan 6;15(1):67-78
pubmed: 19111882
Elife. 2019 Aug 19;8:
pubmed: 31424385
Cell Mol Life Sci. 2013 Feb;70(4):661-87
pubmed: 22864622
Nat Commun. 2016 Sep 14;7:12674
pubmed: 27624869
J Cell Biol. 2013 Apr 1;201(1):65-79
pubmed: 23547029
Biochim Biophys Acta. 2010 Dec;1806(2):230-9
pubmed: 20708655
Nature. 2008 Jun 19;453(7198):1132-6
pubmed: 18463638
Curr Biol. 2003 Apr 15;13(8):691-7
pubmed: 12699628
Elife. 2018 Aug 02;7:
pubmed: 30070631
Front Oncol. 2015 Dec 21;5:290
pubmed: 26734572
Mol Cell. 2003 Oct;12(4):851-62
pubmed: 14580337
Front Oncol. 2016 Jan 18;5:307
pubmed: 26835416
Nat Cell Biol. 2011 Aug 07;13(9):1108-15
pubmed: 21822277
Trends Cell Biol. 2017 Jan;27(1):69-81
pubmed: 27746095
J Biol Methods. 2014;1(2):
pubmed: 25606571
J Cell Biol. 2013 Jun 24;201(7):1013-26
pubmed: 23775192
J Cell Biol. 2011 Dec 26;195(7):1103-13
pubmed: 22184196
Elife. 2018 Feb 21;7:
pubmed: 29465396
J Biol Chem. 2001 Dec 7;276(49):46219-24
pubmed: 11551964
J Cell Biol. 2010 Dec 27;191(7):1315-32
pubmed: 21187329
Oncotarget. 2014 Aug 15;5(15):6229-42
pubmed: 25153724
Nat Rev Mol Cell Biol. 2011 Jun 02;12(7):427-38
pubmed: 21633387
Nat Cell Biol. 2003 Mar;5(3):242-8
pubmed: 12577065
Elife. 2014 May 27;3:e02667
pubmed: 24867643
Science. 2008 Jun 20;320(5883):1655-8
pubmed: 18566290
Nature. 2008 Sep 4;455(7209):119-23
pubmed: 18615013
FEBS Lett. 2002 May 22;519(1-3):59-65
pubmed: 12023018
Mol Cell Proteomics. 2014 Sep;13(9):2411-25
pubmed: 24857844
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11960-5
pubmed: 19617534
Cell Rep. 2017 Dec 19;21(12):3483-3497
pubmed: 29262328
J Cell Sci. 2007 Sep 1;120(Pt 17):2987-96
pubmed: 17715155
Front Oncol. 2015 Dec 21;5:285
pubmed: 26732741
Open Biol. 2018 Jun;8(6):
pubmed: 29899121
Nat Med. 2019 Jan;25(1):111-118
pubmed: 30478424
J Cell Sci. 2018 Apr 12;131(7):
pubmed: 29555820
J Cell Biol. 2019 Feb 4;218(2):383-384
pubmed: 30635354
Chromosoma. 2017 Feb;126(1):93-103
pubmed: 27106516
Essays Biochem. 2010;47:85-98
pubmed: 20533902
ACS Chem Biol. 2011 Jul 15;6(7):685-91
pubmed: 21506563
J Cell Biol. 2019 Feb 4;218(2):422-432
pubmed: 30602538
PLoS Genet. 2015 Jul 02;11(7):e1005345
pubmed: 26134678
J Cell Biol. 2002 Aug 19;158(4):617-23
pubmed: 12177045
Mol Biol Cell. 2015 Dec 1;26(24):4325-32
pubmed: 26446837
Mol Cell Biol. 2005 Dec;25(23):10516-27
pubmed: 16287863
J Cell Biol. 2003 Jun 9;161(5):899-909
pubmed: 12782683
Mol Biol Cell. 2011 Apr 15;22(8):1207-16
pubmed: 21325626
EMBO J. 2014 Feb 18;33(4):385-99
pubmed: 24510915
Genes Dev. 2002 Sep 1;16(17):2274-85
pubmed: 12208850
Biochem J. 2018 Jun 26;475(12):2025-2042
pubmed: 29946042