Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
30 09 2019
30 09 2019
Historique:
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
ppublish
Résumé
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient
Identifiants
pubmed: 32395697
doi: 10.1038/s42255-019-0115-y
pmc: PMC7212038
mid: EMS84126
pii: 10.1038/s42255-019-0115-y
doi:
Substances chimiques
Succinic Acid
AB6MNQ6J6L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
966-974Subventions
Organisme : Wellcome Trust
ID : 110158
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00015/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105674181
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12022/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105663142
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/M015769/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 110159
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 110158/Z/15/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interests The authors declare competing interests. MPM, TK AND RCH have submitted a patent application on the use of dimethyl malonate to prevent ischaemia reperfusion injury.
Références
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