Investigating Human Mitochondrial Genomes in Single Cells.
Cell Line, Tumor
Computational Biology
DNA, Mitochondrial
/ genetics
Databases, Genetic
Datasets as Topic
Genome, Mitochondrial
HT29 Cells
High-Throughput Nucleotide Sequencing
/ methods
Human Umbilical Vein Endothelial Cells
Humans
Leukemia, Erythroblastic, Acute
/ pathology
Sequence Alignment
Single-Cell Analysis
/ methods
Software
mtDNA
scWGS
single-cell
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
11 05 2020
11 05 2020
Historique:
received:
28
02
2020
revised:
07
05
2020
accepted:
08
05
2020
entrez:
15
5
2020
pubmed:
15
5
2020
medline:
16
3
2021
Statut:
epublish
Résumé
Mitochondria host multiple copies of their own small circular genome that has been extensively studied to trace the evolution of the modern eukaryotic cell and discover important mutations linked to inherited diseases. Whole genome and exome sequencing have enabled the study of mtDNA in a large number of samples and experimental conditions at single nucleotide resolution, allowing the deciphering of the relationship between inherited mutations and phenotypes and the identification of acquired mtDNA mutations in classical mitochondrial diseases as well as in chronic disorders, ageing and cancer. By applying an
Identifiants
pubmed: 32403285
pii: genes11050534
doi: 10.3390/genes11050534
pmc: PMC7290567
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Nucleic Acids Res. 2017 Jan 4;45(D1):D698-D706
pubmed: 27899581
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11923-8
pubmed: 26340991
Front Cell Dev Biol. 2016 Aug 18;4:85
pubmed: 27588285
BMC Genomics. 2014;15 Suppl 3:S2
pubmed: 25077682
Biochem J. 2003 Mar 15;370(Pt 3):751-62
pubmed: 12467494
Elife. 2019 Apr 09;8:
pubmed: 30958261
BMC Genomics. 2011 Oct 20;12:517
pubmed: 22013967
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
Bioinformatics. 2010 Apr 1;26(7):873-81
pubmed: 20147302
BMC Bioinformatics. 2004 Aug 19;5:113
pubmed: 15318951
Am J Hum Genet. 2012 Apr 6;90(4):675-84
pubmed: 22482806
Science. 2012 Dec 21;338(6114):1622-6
pubmed: 23258894
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Nucleic Acids Res. 2012 Jan;40(Database issue):D1150-9
pubmed: 22139932
Mitochondrion. 2019 May;46:302-306
pubmed: 30098421
Nat Rev Genet. 2015 Sep;16(9):530-42
pubmed: 26281784
Nat Rev Genet. 2016 Mar;17(3):175-88
pubmed: 26806412
Bioinformatics. 2017 May 1;33(9):1399-1401
pubmed: 28453676
Nucleic Acids Res. 2016 Jan 4;44(D1):D862-8
pubmed: 26582918
Cell. 2019 Mar 7;176(6):1325-1339.e22
pubmed: 30827679
Biomed Rep. 2016 Mar;4(3):259-262
pubmed: 26998260
J Mol Evol. 1995 Jun;40(6):652-7
pubmed: 7543951
Hum Mutat. 2009 Feb;30(2):E386-94
pubmed: 18853457
J Mol Evol. 1994 Aug;39(2):174-90
pubmed: 7932781
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D514-7
pubmed: 15608251
Bioinformatics. 2014 Nov 1;30(21):3115-7
pubmed: 25028726
Commun Biol. 2019 Apr 29;2:147
pubmed: 31044172
Genome Biol. 2011;12(6):R59
pubmed: 21699709
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
J Cell Sci. 2007 Mar 1;120(Pt 5):838-48
pubmed: 17298981
J Mol Evol. 1999 Apr;48(4):427-34
pubmed: 10079281
Nat Commun. 2017 Sep 22;8(1):656
pubmed: 28939825
Nucleic Acids Res. 2019 Jan 8;47(D1):D1202-D1210
pubmed: 30371888
PLoS Genet. 2010 Feb 12;6(2):e1000834
pubmed: 20168995
Genome Res. 2001 Jun;11(6):1095-9
pubmed: 11381035
Nat Methods. 2012 May 30;9(6):523-4
pubmed: 22669646
Nat Methods. 2017 May;14(5):491-493
pubmed: 28319112
Environ Mol Mutagen. 2010 Jun;51(5):440-50
pubmed: 20544884
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Nat Genet. 1999 Oct;23(2):147
pubmed: 10508508
Sci Rep. 2017 Nov 27;7(1):16357
pubmed: 29180746
Genomics. 1992 Jul;13(3):718-25
pubmed: 1639399
Mitochondrion. 2020 Jan;50:88-93
pubmed: 31669622
Curr Protoc Hum Genet. 2011 Oct;Chapter 19:Unit19.8
pubmed: 21975941
J Med Genet. 2008 Dec;45(12):769-72
pubmed: 18611982
Adv Exp Med Biol. 2017;982:577-594
pubmed: 28551808
Cold Spring Harb Perspect Biol. 2013 Nov 01;5(11):a021220
pubmed: 24186072
Curr Protoc Bioinformatics. 2013 Dec;44:1.23.1-26
pubmed: 25489354