Disease-Specific Derangement of Circulating Endocannabinoids and


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
11 May 2020
Historique:
received: 10 04 2020
revised: 06 05 2020
accepted: 09 05 2020
entrez: 15 5 2020
pubmed: 15 5 2020
medline: 23 2 2021
Statut: epublish

Résumé

Growing evidence highlights the endocannabinoid (EC) system involvement in cancer progression. Lipid mediators of this system are secreted by hematopoietic cells, including the ECs 2-arachidonoyl-glycerol (2AG) and arachidonoyl-ethanolamide (AEA), the 2AG metabolite 1AG, and members of N-acylethanolamine (NAE) family-palmitoyl-ethanolamide (PEA) and oleoyl-ethanolamide (OEA). However, the relevance of the EC system in myeloproliferative neoplasms (MPN) was never investigated. We explored the EC plasma profile in 55 MPN patients, including myelofibrosis (MF;

Identifiants

pubmed: 32403407
pii: ijms21093399
doi: 10.3390/ijms21093399
pmc: PMC7246996
pii:
doi:

Substances chimiques

Amides 0
Arachidonic Acids 0
Endocannabinoids 0
Ethanolamines 0
Glycerides 0
N-acylethanolamines 0
Oleic Acids 0
Palmitic Acids 0
Polyunsaturated Alkamides 0
oleoylethanolamide 1HI5J9N8E6
palmidrol 6R8T1UDM3V
glyceryl 2-arachidonate 8D239QDW64
JAK2 protein, human EC 2.7.10.2
Janus Kinase 2 EC 2.7.10.2
anandamide UR5G69TJKH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 20930
Organisme : SIE-Società Italiana di Ematologia- e Associazione "Amici di Beat Leukemia Dr. Alessandro Cevenini ONLUS
ID : /

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Auteurs

Dorian Forte (D)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Flaminia Fanelli (F)

Unit of Endocrinology and Prevention and Care of Diabetes, Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna, University-Hospital S.Orsola, 40138 Bologna, Italy.

Marco Mezzullo (M)

Unit of Endocrinology and Prevention and Care of Diabetes, Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna, University-Hospital S.Orsola, 40138 Bologna, Italy.

Martina Barone (M)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Giulia Corradi (G)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Giuseppe Auteri (G)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Daniela Bartoletti (D)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Marina Martello (M)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Emanuela Ottaviani (E)

Institute of Hematology "L. e A. Seràgnoli", Department of Oncology and Hematology, University-Hospital S.Orsola, 40138 Bologna, Italy.

Carolina Terragna (C)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Antonio Curti (A)

Institute of Hematology "L. e A. Seràgnoli", Department of Oncology and Hematology, University-Hospital S.Orsola, 40138 Bologna, Italy.

Uberto Pagotto (U)

Unit of Endocrinology and Prevention and Care of Diabetes, Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, University of Bologna, University-Hospital S.Orsola, 40138 Bologna, Italy.

Francesca Palandri (F)

Institute of Hematology "L. e A. Seràgnoli", Department of Oncology and Hematology, University-Hospital S.Orsola, 40138 Bologna, Italy.

Michele Cavo (M)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

Lucia Catani (L)

Institute of Hematology "L. e A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, 40138 Bologna, Italy.

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