Cytosolic Events in the Biogenesis of Mitochondrial Proteins.
RNA-binding proteins
chaperones
mitochondrial precursor
mitochondrial protein import
mitochondrial targeting sequence
nascent-chain associated complex
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
01
2020
revised:
18
03
2020
accepted:
02
04
2020
pubmed:
16
5
2020
medline:
22
6
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
While targeting of proteins synthesized in the cytosol to any organelle is complex, mitochondria present the most challenging of destinations. First, import of nuclear-encoded proteins needs to be balanced with production of mitochondrial-encoded ones. Moreover, as mitochondria are divided into distinct subdomains, their proteins harbor a number of different targeting signals and biophysical properties. While translocation into the mitochondrial membranes has been well studied, the cytosolic steps of protein import remain poorly understood. Here, we review current knowledge on mRNA and protein targeting to mitochondria, as well as recent advances in our understanding of the cellular programs that respond to accumulation of mitochondrial precursor proteins in the cytosol, thus linking defects in targeting-capacity to signaling.
Identifiants
pubmed: 32409196
pii: S0968-0004(20)30091-8
doi: 10.1016/j.tibs.2020.04.001
pii:
doi:
Substances chimiques
Heat-Shock Proteins
0
Mitochondrial Proteins
0
Signal Recognition Particle
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
650-667Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.