First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study.
Aged
Betacoronavirus
COVID-19
Comorbidity
Coronavirus Infections
/ epidemiology
Disease Transmission, Infectious
/ prevention & control
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Organ Transplantation
/ methods
Pandemics
Pneumonia, Viral
/ epidemiology
Postoperative Complications
/ epidemiology
Prospective Studies
SARS-CoV-2
Survival Rate
/ trends
Switzerland
/ epidemiology
Transplant Recipients
clinical research/ practice
complication: infectious
infection and infectious agents
infection and infectious agents - viral
infectious disease
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
04
2020
revised:
04
05
2020
accepted:
05
05
2020
pubmed:
16
5
2020
medline:
21
10
2020
entrez:
16
5
2020
Statut:
ppublish
Résumé
Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data of SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety-five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow-up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.
Identifiants
pubmed: 32412159
doi: 10.1111/ajt.16062
pmc: PMC7272999
pii: S1600-6135(22)22476-9
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2876-2882Subventions
Organisme : Swiss University Hospitals (G15)
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 33CS30_177522
Pays : International
Investigateurs
Patrizia Amico
(P)
John-David Aubert
(JD)
Vanessa Banz
(V)
Guido Beldi
(G)
Christian Benden
(C)
Christoph Berger
(C)
Isabelle Binet
(I)
Pierre-Yves Bochud
(PY)
Sanda Branca
(S)
Heiner Bucher
(H)
Thierry Carell
(T)
Emmanuelle Catana
(E)
Yves Chalandon
(Y)
Sabina de Geest
(S)
Olivier de Rougemont
(O)
Michael Dickenmann
(M)
Michel Duchosal
(M)
Laure Elkrief
(L)
Thomas Fehr
(T)
Sylvie Ferrari-Lacraz
(S)
Christian Garzoni
(C)
Paola Gasche Soccal
(PG)
Christophe Gaudet
(C)
Emiliano Giostra
(E)
Déla Golshayan
(D)
Karine Hadaya
(K)
Jörg Halter
(J)
Dimitri Hauri
(D)
Dominik Heim
(D)
Christoph Hess
(C)
Sven Hillinger
(S)
Hans H Hirsch
(HH)
Günther Hofbauer
(G)
Uyen Huynh-Do
(U)
Franz Immer
(F)
Richard Klaghofer
(R)
Michael Koller
(M)
Bettina Laesser
(B)
Guido Laube
(G)
Roger Lehmann
(R)
Christian Lovis
(C)
Pietro Majno
(P)
Oriol Manuel
(O)
Hans-Peter Marti
(HP)
Pierre Yves Martin
(PY)
Michele Martinelli
(M)
Pascal Meylan
(P)
Nicolas J Mueller
(NJ)
Antonia Müller
(A)
Thomas Müller
(T)
Beat Müllhaupt
(B)
Manuel Pascual
(M)
Jakob Passweg
(J)
Klara Posfay-Barbe
(K)
Juliane Rick
(J)
Eddy Roosnek
(E)
Anne Rosselet
(A)
Silvia Rothlin
(S)
Frank Ruschitzka
(F)
Urs Schanz
(U)
Stefan Schaub
(S)
Aurelia Schnyder
(A)
Macé Schuurmans
(M)
Christian Seiler
(C)
Jan Sprachta
(J)
Susanne Stampf
(S)
Carolin Steinack
(C)
Jürg Steiger
(J)
Guido Stirnimann
(G)
Christian Toso
(C)
Christian Van Delden
(C)
Jean-Pierre Venetz
(JP)
Jean Villard
(J)
Madeleine Wick
(M)
Markus Wilhelm
(M)
Patrick Yerly
(P)
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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