Insights into the degradation chemistry of tazarotene, a third generation acetylenic retinoid: LC-HRMS (Orbitrap), LC-MS
ADMET predictor™
Degradation products
LC–MS
NMR
Stress testing
Tazarotene
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
29
01
2020
revised:
13
04
2020
accepted:
13
04
2020
pubmed:
16
5
2020
medline:
5
5
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
Tazarotene is a prodrug that belongs to the acetylenic class of retinoids. The drug was subjected to hydrolytic, oxidative and photolytic stress testing to establish its comprehensive degradation chemistry. The drug proved to be unstable under acidic and basic hydrolytic conditions, yielding tazarotenic acid, which is a known major degradation product (DP) and an active metabolite. Additionally, two DPs each were generated upon interaction of drug and tazarotenic acid with HCl, used as an acid stressor. These were experimentally proven as pseudo DPs, as they did not originate when H
Identifiants
pubmed: 32413825
pii: S0731-7085(20)30239-9
doi: 10.1016/j.jpba.2020.113316
pii:
doi:
Substances chimiques
Dermatologic Agents
0
Nicotinic Acids
0
tazarotene
81BDR9Y8PS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113316Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have declared no conflict of interest.