Role of enterotoxigenic Escherichia coli prophage in spreading antibiotic resistance in a porcine-derived environment.
Journal
Environmental microbiology
ISSN: 1462-2920
Titre abrégé: Environ Microbiol
Pays: England
ID NLM: 100883692
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
07
11
2019
accepted:
13
05
2020
pubmed:
19
5
2020
medline:
7
4
2021
entrez:
19
5
2020
Statut:
ppublish
Résumé
Enterotoxigenic Escherichia coli (ETEC) cause acute secretory diarrhoea in pigs, posing a great economic loss to the swine industry. This study analysed the prevalence and genetic characteristics of prophages from 132 ETEC isolates from symptomatic pigs to determine their potential for spreading antibiotic resistance. A total of 1105 potential prophages were identified, and the distribution of the genome size showed three 'overlapping' trends. Similarity matrix comparison showed that prophages correlated with the ETEC lineage distribution, and further identification of these prophages corroborated the lineage specificity. In total, 1206 antibiotic resistance genes (ARGs) of 52 different categories were identified in 132 ETEC strains; among these, 2.65% (32/1206) of ARGs were found to be carried by prophages. Analysis of flanking sequences showed that almost all the ARGs could be grouped into two types: 'bla
Identifiants
pubmed: 32419209
doi: 10.1111/1462-2920.15084
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4974-4984Subventions
Organisme : Graduate Student Overseas Study Program from South China Agricultural University
ID : 2018LHPY006
Organisme : Major Scientific Research Projects of Guangdong Provincial
ID : 2017KZDXM006
Informations de copyright
© 2020 Society for Applied Microbiology and John Wiley & Sons Ltd.
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