Serum IL-23, E-selectin and sICAM levels in non-small cell lung cancer patients before and after radiotherapy.
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Biomarkers, Tumor
/ blood
Carcinoma, Non-Small-Cell Lung
/ blood
Chemoradiotherapy
/ methods
Dose Fractionation, Radiation
Dose-Response Relationship, Radiation
E-Selectin
/ blood
Female
Humans
Intercellular Adhesion Molecule-1
/ blood
Interleukin-23
/ blood
Lung Neoplasms
/ blood
Male
Middle Aged
Prognosis
Radiotherapy, Intensity-Modulated
/ methods
Treatment Outcome
E-selectin
IL-23
NSCLC
inflammation
radiotherapy
sICAM
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
entrez:
19
5
2020
pubmed:
19
5
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
The functions of E-selectin, interleukin (IL)-23, and soluble intercellular adhesion molecule (sICAM) in patients with non-small cell lung cancer (NSCLC) patients before and after radiotherapy (RT) are poorly understood. The purpose of our study was to investigate serum IL-23, E-selectin and sICAM levels in NSCLC patients before and after RT. Forty-four patients with pathologically confirmed NSCLC and 30 healthy individuals were included in the study. All patients received 66.6 Gy of concurrent RT. Significant differences were observed between serum IL-23, E-selectin and sICAM levels in controls and NSCLC patients both before and after radiotherapy. Inverse correlations were detected between serum IL-23 and E-selectin levels in NSCLC patients before and after RT. Positive correlations were detected between serum sICAM levels of NSCLC patients before and after RT and RT dose. No associations were observed between RT dose and IL-23 or E-selectin levels in patients before and after RT. Serum IL-23, E-selectin and sICAM levels were elevated in NSCLC patients. While our results demonstrate the prognostic value of these parameters, further molecular studies of NSCLC patients are warranted.
Identifiants
pubmed: 32419551
doi: 10.1177/0300060520923493
pmc: PMC7235674
doi:
Substances chimiques
Biomarkers, Tumor
0
E-Selectin
0
ICAM1 protein, human
0
Interleukin-23
0
SELE protein, human
0
Intercellular Adhesion Molecule-1
126547-89-5
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
300060520923493Références
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