Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves.
Animals
Blood Glucose
/ metabolism
Enteroendocrine Cells
/ metabolism
Gastric Inhibitory Polypeptide
/ metabolism
Glucagon-Like Peptide 1
/ metabolism
Glucagon-Like Peptide-1 Receptor
/ metabolism
Glucose
/ metabolism
Incretins
/ metabolism
Postprandial Period
Rats
Receptors, Gastrointestinal Hormone
Substance P
/ metabolism
TRPA1 Cation Channel
/ metabolism
GPCR
incretin
intestine
mesenteric lymph
neuropeptide
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
pubmed:
19
5
2020
medline:
21
10
2020
entrez:
19
5
2020
Statut:
ppublish
Résumé
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells (EECs) in response to nutrient ingestion and lower blood glucose levels by stimulation of insulin secretion and thus are defined as incretins. GLP-1 receptor (GLP-1R) expression has been identified on enteric neurons that include intrinsic afferent neurons, extrinsic spinal, and vagal sensory afferents but has not been shown to have an incretin effect through these nerves. GLP-1 and GIP enter the mesenteric lymphatic fluid (MLF) after a meal via the interstitial fluid (IF) from local tissue secretion and/or blood capillaries. We tested if MLF could induce diet-dependent intransient increases in intracellular calcium ([Ca
Identifiants
pubmed: 32421358
doi: 10.1152/ajpgi.00189.2019
pmc: PMC7468754
doi:
Substances chimiques
Blood Glucose
0
Glucagon-Like Peptide-1 Receptor
0
Incretins
0
Receptors, Gastrointestinal Hormone
0
TRPA1 Cation Channel
0
Substance P
33507-63-0
Gastric Inhibitory Polypeptide
59392-49-3
Glucagon-Like Peptide 1
89750-14-1
gastric inhibitory polypeptide receptor
D6H00MV7K8
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
G23-G35Références
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