Association of Dietary Fatty Acid Consumption Patterns with Risk of Hyper-LDL Cholesterolemiain Korean Adults.
Adult
Aged
Cholesterol, LDL
/ blood
Diet
/ adverse effects
Diet Surveys
Dietary Fats
/ adverse effects
Eating
/ physiology
Fatty Acids
/ adverse effects
Female
Heart Disease Risk Factors
Humans
Hypercholesterolemia
/ blood
Male
Middle Aged
Principal Component Analysis
Prospective Studies
Republic of Korea
/ epidemiology
Sex Factors
Korean Genome and Epidemiology Study (KoGES)
cohort study
dietary fatty acids
hyper-LDL cholesterolemia
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
received:
10
04
2020
revised:
08
05
2020
accepted:
12
05
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
10
2
2021
Statut:
epublish
Résumé
This study aimed to identify the association between the risk of hyper-LDL cholesterolemia (hyper-LDLC) and fatty acid consumption patterns (FACPs) using the data from the Korean Genome and Epidemiology Study (KoGES) prospective cohort. A total of 6542 middle-aged Korean adults were included in the analysis. Four FACPs were identified through principal component analysis of the reported intakes of 34 fatty acids (FAs): "long-chain FA pattern"; "short & medium-chain saturated fatty acid (SFA) pattern"; "n-3 polyunsaturated fatty acid (PUFA) pattern"; and "long-chain SFA pattern". The "long-chain SFA pattern" lowered the risk of hyper-LDLC (relative risk (RR), 0.82; 95% confidence interval (CI), 0.72-0.94; p for trend, 0.004) and the "short & medium-chain SFA pattern" increased the risk of hyper-LDLC (RR, 1.17; 95% CI, 1.03-1.32; p for trend = 0.004). In sex-stratified analyses, the associations of the "long-chain SFA pattern" (RR, 0.73; 95% CI, 0.58-0.93; p for trend = 0.007) and the "short & medium-chain SFA pattern" (RR, 1.34; 95% CI, 1.07-1.69; p for trend = 0.003) with the hyper-LDLC risk were observed only in men, but not in women. These results suggest that FACPs with a high intake of long-chain SFA or a low intake of short and medium-chain SFA may protect Korean adults from hyper-LDLC.
Identifiants
pubmed: 32422908
pii: nu12051412
doi: 10.3390/nu12051412
pmc: PMC7284755
pii:
doi:
Substances chimiques
Cholesterol, LDL
0
Dietary Fats
0
Fatty Acids
0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2018R1A2B6007070
Déclaration de conflit d'intérêts
The authors declare no potential conflicts of interest.
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