Semi-rational approach to expand the Acyl-CoA Chain length tolerance of Sphingomonas paucimobilis serine palmitoyltransferase.
C-C bond-forming reaction
Enzyme engineering
Enzyme library screening
Serine palmitoyltransferase
Sphingolipids
Substrate tolerance
Journal
Enzyme and microbial technology
ISSN: 1879-0909
Titre abrégé: Enzyme Microb Technol
Pays: United States
ID NLM: 8003761
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
03
10
2019
revised:
11
01
2020
accepted:
20
01
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
1
12
2020
Statut:
ppublish
Résumé
Serine palmitoyltransferase (SPTase), the first enzyme of the sphingolipid biosynthesis pathway, produces 3-ketodihydrosphingosine by a Claisen-like condensation/decarboxylation reaction of l-Ser and palmitoyl-CoA (n-C
Identifiants
pubmed: 32423667
pii: S0141-0229(20)30008-9
doi: 10.1016/j.enzmictec.2020.109515
pmc: PMC7239952
mid: NIHMS1562421
pii:
doi:
Substances chimiques
Acyl Coenzyme A
0
Bacterial Proteins
0
ketodihydrosphingosine
16105-69-4
Serine C-Palmitoyltransferase
EC 2.3.1.50
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109515Subventions
Organisme : NIH HHS
ID : S10 OD021758
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest There are no conflicts to declare.
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