The microbiome of alpine snow algae shows a specific inter-kingdom connectivity and algae-bacteria interactions with supportive capacities.


Journal

The ISME journal
ISSN: 1751-7370
Titre abrégé: ISME J
Pays: England
ID NLM: 101301086

Informations de publication

Date de publication:
09 2020
Historique:
received: 12 01 2020
accepted: 01 05 2020
revised: 25 04 2020
pubmed: 20 5 2020
medline: 26 1 2021
entrez: 20 5 2020
Statut: ppublish

Résumé

Mutualistic interactions within microbial assemblages provide a survival strategy under extreme conditions; however, little is known about the complexity of interaction networks in multipartite, free-living communities. In the present study, the interplay within algae-dominated microbial communities exposed to harsh environmental influences in the Austrian Alps was assessed in order to reveal the interconnectivity of eukaryotic and prokaryotic inhabitants. All analyzed snowfields harbored distinct microbial communities. Network analyses revealed that mutual exclusion prevailed among microalgae in the alpine environment, while bacteria were mainly positively embedded in the interaction networks. Especially members of Proteobacteria, with a high prevalence of Oxalobacteraceae, Pseudomonadaceae, and Sphingomonadaceae showed genus-specific co-occurrences with distinct microalgae. Co-cultivation experiments with algal and bacterial isolates confirmed beneficial interactions that were predicted based on the bioinformatic analyses; they resulted in up to 2.6-fold more biomass for the industrially relevant microalga Chlorella vulgaris, and up to 4.6-fold increase in biomass for the cryophilic Chloromonas typhlos. Our findings support the initial hypothesis that microbial communities exposed to adverse environmental conditions in alpine systems harbor inter-kingdom supportive capacities. The insights into mutualistic inter-kingdom interactions and the ecology of microalgae within complex microbial communities provide explanations for the prevalence and resilience of such assemblages in alpine environments.

Identifiants

pubmed: 32424246
doi: 10.1038/s41396-020-0677-4
pii: 10.1038/s41396-020-0677-4
pmc: PMC7608445
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2197-2210

Références

Kouzuma A, Watanabe K. Exploring the potential of algae/bacteria interactions. Curr Opin Biotechnol. 2015;33:125–9.
pubmed: 25744715 doi: 10.1016/j.copbio.2015.02.007
Eigemann F, Hilt S, Salka I, Grossart H-P. Bacterial community composition associated with freshwater algae: species specificity vs. dependency on environmental conditions and source community. FEMS Microbiol Ecol. 2013;83:650–63.
pubmed: 23030046 doi: 10.1111/1574-6941.12022
Amin SA, Parker MS, Armbrust EV. Interactions between diatoms and bacteria. Microbiol Mol Biol Rev. 2012;76:667–84.
pubmed: 22933565 pmcid: 3429620 doi: 10.1128/MMBR.00007-12
Cole JJ. Interactions between bacteria and algae in aquatic ecosystems. Annu Rev Ecol Syst. 1982;13:291–314.
doi: 10.1146/annurev.es.13.110182.001451
Anesio AM, Laybourn-Parry J. Glaciers and ice sheets as a biome. Trends Ecol Evol. 2012;27:219–25.
pubmed: 22000675 doi: 10.1016/j.tree.2011.09.012
Berg G, Rybakova D, Grube M, Köberl M. The plant microbiome explored: implications for experimental botany. J Exp Bot. 2016;67:995–1002.
pubmed: 26547794 doi: 10.1093/jxb/erv466
Philippot L, Raaijmakers JM, Lemanceau P, van der Putten WH. Going back to the roots: the microbial ecology of the rhizosphere. Nat Rev Microbiol. 2013;11:789–99.
pubmed: 24056930 doi: 10.1038/nrmicro3109
Cooper MB, Smith AG. Exploring mutualistic interactions between microalgae and bacteria in the omics age. Curr Opin Plant Biol. 2015;26:147–53.
pubmed: 26318329 doi: 10.1016/j.pbi.2015.07.003
Kim B-H, Ramanan R, Cho D-H, Oh H-M, Kim H-S. Role of Rhizobium, a plant growth promoting bacterium, in enhancing algal biomass through mutualistic interaction. Biomass Bioenergy. 2014;69:95–105.
doi: 10.1016/j.biombioe.2014.07.015
Ramanan R, Kang Z, Kim B-H, Cho D-H, Jin L, Oh H-M, et al. Phycosphere bacterial diversity in green algae reveals an apparent similarity across habitats. Algal Res. 2015;8:140–4.
doi: 10.1016/j.algal.2015.02.003
Croft MT, Warren MJ, Smith AG. Algae need their vitamins. Eukaryot Cell. 2006;5:1175–83.
pubmed: 16896203 pmcid: 1539151 doi: 10.1128/EC.00097-06
Amavizca E, Bashan Y, Ryu C-M, Farag MA, Bebout BM, de-Bashan LE. Enhanced performance of the microalga Chlorella sorokiniana remotely induced by the plant growth-promoting bacteria Azospirillum brasilense and Bacillus pumilus. Sci Rep. 2017;7:41310.
pubmed: 28145473 pmcid: 5286510 doi: 10.1038/srep41310
Goecke F, Labes A, Wiese J, Imhoff JF. Chemical interactions between marine macroalgae and bacteria. Mar Ecol Prog Ser. 2010;409:267–99.
doi: 10.3354/meps08607
Joint I, Tait K, Callow ME, Callow JA, Milton D, Williams P, et al. Cell-to-cell communication across the prokaryote-eukaryote boundary. Science. 2002;298:1207.
pubmed: 12424372 doi: 10.1126/science.1077075
Brennan L, Owende P. Biofuels from microalgae—a review of technologies for production, processing, and extractions of biofuels and co-products. Renew Sustain Energy Rev. 2010;14:557–77.
doi: 10.1016/j.rser.2009.10.009
Spolaore P, Joannis-Cassan C, Duran E, Isambert A. Commercial applications of microalgae. J Biosci Bioeng. 2006;10:87–96.
doi: 10.1263/jbb.101.87
Fulbright SP, Robbins-Pianka A, Berg-Lyons D, Knight R, Reardon KF, Chisholm ST. Bacterial community changes in an industrial algae production system. Algal Res. 2018;31:147–56.
pubmed: 29785358 pmcid: 5959032 doi: 10.1016/j.algal.2017.09.010
Kazamia E, Aldridge DC, Smith AG. Synthetic ecology—a way forward for sustainable algal biofuel production? J Biotechnol. 2012;162:163–9.
doi: 10.1016/j.jbiotec.2012.03.022
Hardin G. The competitive exclusion principle. Science. 1960;131:1292–7.
pubmed: 14399717 doi: 10.1126/science.131.3409.1292
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990;215:403–10.
doi: 10.1016/S0022-2836(05)80360-2 pubmed: 2231712
Kumar S, Stecher G, Li M, Knyaz C, Tamura K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol. 2018;35:1547–9.
pubmed: 29722887 pmcid: 5967553 doi: 10.1093/molbev/msy096
Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987;4:406–25.
pubmed: 3447015
Felsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evol Int J Org Evol. 1985;39:783–91.
doi: 10.1111/j.1558-5646.1985.tb00420.x
Tamura K, Nei M, Kumar S. Prospects for inferring very large phylogenies by using the neighbor-joining method. Proc Natl Acad Sci USA. 2004;101:11030–5.
pubmed: 15258291 doi: 10.1073/pnas.0404206101 pmcid: 491989
Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turnbaugh PJ, et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci USA 2011;108:4516–22.
pubmed: 20534432 doi: 10.1073/pnas.1000080107
Lundberg DS, Yourstone S, Mieczkowski P, Jones CD, Dangl JL. Practical innovations for high-throughput amplicon sequencing. Nat Methods. 2013;10:999–1002.
pubmed: 23995388 doi: 10.1038/nmeth.2634
Amaral-Zettler LA, McCliment EA, Ducklow HW, Huse SM. A method for studying protistan diversity using massively parallel sequencing of V9 hypervariable regions of small-subunit ribosomal RNA genes. PLoS ONE 2009;4:e6372.
pubmed: 19633714 pmcid: 2711349 doi: 10.1371/journal.pone.0006372
Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010;7:335–6.
pubmed: 20383131 pmcid: 3156573 doi: 10.1038/nmeth.f.303
Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA, Holmes SP. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13:581–3.
pubmed: 27214047 pmcid: 4927377 doi: 10.1038/nmeth.3869
Rognes T, Flouri T, Nichols B, Quince C, Mahé F. VSEARCH: a versatile open source tool for metagenomics. PeerJ 2016;4:e2584.
pubmed: 27781170 pmcid: 5075697 doi: 10.7717/peerj.2584
Lozupone C, Knight R. UniFrac: a new phylogenetic method for comparing microbial communities. Appl Env Microbiol. 2005;71:8228–35.
doi: 10.1128/AEM.71.12.8228-8235.2005
Katoh K, Standley DM. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol. 2013;30:772–80.
pubmed: 23329690 pmcid: 3603318 doi: 10.1093/molbev/mst010
Price MN, Dehal PS, Arkin AP. FastTree 2—approximately maximum-likelihood trees for large alignments. PLoS ONE 2010;5:e9490.
pubmed: 20224823 pmcid: 2835736 doi: 10.1371/journal.pone.0009490
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–504.
pubmed: 14597658 pmcid: 403769 doi: 10.1101/gr.1239303
Faust K, Raes J. CoNet app: inference of biological association networks using Cytoscape. F1000Research. 2016;5:1519.
pubmed: 27853510 pmcid: 5089131 doi: 10.12688/f1000research.9050.1
Arndt D, Xia J, Liu Y, Zhou Y, Guo AC, Cruz JA, et al. METAGENassist: a comprehensive web server for comparative metagenomics. Nucleic Acids Res. 2012;40:W88–95.
pubmed: 22645318 pmcid: 3394294 doi: 10.1093/nar/gks497
Morohoshi T, Kato M, Fukamachi K, Kato N, Ikeda T. N-Acylhomoserine lactone regulates violacein production in Chromobacterium violaceum type strain ATCC 12472. FEMS Microbiol Lett. 2008;279:124–30.
pubmed: 18177311 doi: 10.1111/j.1574-6968.2007.01016.x
McClean KH, Winson MK, Fish L, Taylor A, Chhabra SR, Camara M, et al. Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiol Read Engl. 1997;143:3703–11.
doi: 10.1099/00221287-143-12-3703
Adam E, Müller H, Erlacher A, Berg G. Complete genome sequences of the Serratia plymuthica strains 3Rp8 and 3Re4-18, two rhizosphere bacteria with antagonistic activity towards fungal phytopathogens and plant growth promoting abilities. Stand Genom Sci. 2016;11:61.
doi: 10.1186/s40793-016-0185-3
Gordon SA, Weber RP. Colorimetric estimation of indoleacetic acid. Plant Physiol. 1951;26:192–5.
pubmed: 16654351 pmcid: 437633 doi: 10.1104/pp.26.1.192
Krug L, Erlacher A, Berg G, Cernava T. A novel, nature-based alternative for photobioreactor decontaminations. Sci Rep. 2019;9:2864.
pubmed: 30814601 pmcid: 6393562 doi: 10.1038/s41598-019-39673-6
Müller H, Berg C, Landa BB, Auerbach A, Moissl-Eichinger C, Berg G. Plant genotype-specific archaeal and bacterial endophytes but similar Bacillus antagonists colonize Mediterranean olive trees. Front Microbiol. 2015;6:138.
pubmed: 25784898 pmcid: 4347506 doi: 10.3389/fmicb.2015.00138
Wassermann B, Cernava T, Müller H, Berg C, Berg G. Seeds of native alpine plants host unique microbial communities embedded in cross-kingdom networks. Microbiome 2019;7:108.
pubmed: 31340847 pmcid: 6651914 doi: 10.1186/s40168-019-0723-5
Segawa T, Matsuzaki R, Takeuchi N, Akiyoshi A, Navarro F, Sugiyama S, et al. Bipolar dispersal of red-snow algae. Nat Commun. 2018;9:3094.
pubmed: 30082897 pmcid: 6079020 doi: 10.1038/s41467-018-05521-w
Remias D, Lütz-Meindl U, Lütz C. Photosynthesis, pigments and ultrastructure of the alpine snow alga Chlamydomonas nivalis. Eur J Phycol. 2005;40:259–68.
doi: 10.1080/09670260500202148
Hamilton TL, Havig J. Primary productivity of snow algae communities on stratovolcanoes of the Pacific Northwest. Geobiology. 2017;15:280–95.
pubmed: 27917584 doi: 10.1111/gbi.12219
Seckbach J. Algae and Cyanobacteria in extreme environments. Springer, Dordrecht, The Netherlands; 2007. 786 p.
Stibal M, Elster J, Šabacká M, Kaštovská K. Seasonal and diel changes in photosynthetic activity of the snow alga Chlamydomonas nivalis (Chlorophyceae) from Svalbard determined by pulse amplitude modulation fluorometry. FEMS Microbiol Ecol. 2007;59:265–73.
pubmed: 17313577 doi: 10.1111/j.1574-6941.2006.00264.x
Bidigare RR, Ondrusek ME, Kennicutt MC, Iturriaga R, Harvey HR, Hoham RW, et al. Evidence a photoprotective for secondary carotenoids of snow algae1. J Phycol. 1993;29:427–34.
doi: 10.1111/j.1529-8817.1993.tb00143.x
Lutz S, Anesio AM, Field K, Benning LG. Integrated ‘Omics’, targeted metabolite and single-cell analyses of arctic snow algae functionality and adaptability. Front Microbiol. 2015;6:1323.
pubmed: 26635781 pmcid: 4659291
Davey MP, Norman L, Sterk P, Huete-Ortega M, Bunbury F, Loh BKW, et al. Snow algae communities in Antarctica: metabolic and taxonomic composition. N. Phytol. 2019;222:1242–55.
doi: 10.1111/nph.15701
Remias D, Jost S, Boenigk J, Wastian J, Lütz C. Hydrurus-related golden algae (Chrysophyceae) cause yellow snow in polar summer snowfields. Phycol Res. 2013;61:277–85.
doi: 10.1111/pre.12025
Tanabe Y, Shitara T, Kashino Y, Hara Y, Kudoh S. Utilizing the effective xanthophyll cycle for blooming of Ochromonas smithii and O. itoi (Chrysophyceae) on the snow surface. PLoS ONE. 2011;6:e14690.
pubmed: 21373183 pmcid: 3044130 doi: 10.1371/journal.pone.0014690
Harding T, Jungblut AD, Lovejoy C, Vincent WF. Microbes in high arctic snow and implications for the cold biosphere. Appl Environ Microbiol. 2011;77:3234–43.
pubmed: 21460114 pmcid: 3126466 doi: 10.1128/AEM.02611-10
Margesin R, Spröer C, Zhang D-C, Busse H-J. Polaromonas glacialis sp. nov. and Polaromonas cryoconiti sp. nov., isolated from alpine glacier cryoconite. Int J Syst Evol Microbiol. 2012;62:2662–8.
pubmed: 22199222 doi: 10.1099/ijs.0.037556-0
Terashima M, Umezawa K, Mori S, Kojima H, Fukui M. Microbial community analysis of colored snow from an alpine snowfield in northern japan reveals the prevalence of betaproteobacteria with snow algae. Front Microbiol. 2017;8:1481.
pubmed: 28824603 pmcid: 5545588 doi: 10.3389/fmicb.2017.01481
Abell GCJ, Bowman JP. Colonization and community dynamics of class Flavobacteria on diatom detritus in experimental mesocosms based on Southern Ocean seawater. FEMS Microbiol Ecol. 2005;53:379–91.
pubmed: 16329957 doi: 10.1016/j.femsec.2005.01.008
Brown SP, Olson BJSC, Jumpponen A. Fungi and algae co-occur in snow: an issue of shared habitat or algal facilitation of heterotrophs? Arct Antarct Alp Res. 2015;47:729–49.
doi: 10.1657/AAAR0014-071
Singh P, Singh SM, Tsuji M, Prasad GS, Hoshino T. Rhodotorula svalbardensis sp. nov., a novel yeast species isolated from cryoconite holes of Ny-Ålesund, Arctic. Cryobiology. 2014;68:122–8.
pubmed: 24463093 doi: 10.1016/j.cryobiol.2014.01.006
Ruisi S, Barreca D, Selbmann L, Zucconi L, Onofri S. Fungi in Antarctica. Rev Environ Sci Biotechnol. 2007;6:127–41.
doi: 10.1007/s11157-006-9107-y
Buzzini P, Branda E, Goretti M, Turchetti B. Psychrophilic yeasts from worldwide glacial habitats: diversity, adaptation strategies and biotechnological potential. FEMS Microbiol Ecol. 2012;82:217–41.
pubmed: 22385361 doi: 10.1111/j.1574-6941.2012.01348.x
Miller MJ. Syntheses and therapeutic potential of hydroxamic acid based siderophores and analogs. Chem Rev. 1989;89:1563–79.
doi: 10.1021/cr00097a011
Atkin CL, Neilands JB, Phaff HJ. Rhodotorulic acid from species of Leucosporidium, Rhodosporidium, Rhodotorula, Sporidiobolus, and Sporobolomyces, and a new alanine-containing ferrichrome from Cryptococcus melibiosum. J Bacteriol. 1970;103:722–33.
pubmed: 5529038 pmcid: 248150 doi: 10.1128/jb.103.3.722-733.1970
Ignatova LV, Brazhnikova YV, Berzhanova RZ, Mukasheva TD. Plant growth-promoting and antifungal activity of yeasts from dark chestnut soil. Microbiol Res. 2015;175:78–83.
pubmed: 25843007 doi: 10.1016/j.micres.2015.03.008
Xin G, Glawe D, Doty SL. Characterization of three endophytic, indole-3-acetic acid-producing yeasts occurring in Populus trees. Mycol Res. 2009;113:973–80.
pubmed: 19539760 doi: 10.1016/j.mycres.2009.06.001
Wang K, Sipilä TP, Overmyer K. The isolation and characterization of resident yeasts from the phylloplane of Arabidopsis thaliana. Sci Rep. 2016;6:39403.
pubmed: 28004784 pmcid: 5177952 doi: 10.1038/srep39403
Gómez-Pereira PR, Schüler M, Fuchs BM, Bennke C, Teeling H, Waldmann J, et al. Genomic content of uncultured Bacteroidetes from contrasting oceanic provinces in the North Atlantic Ocean. Environ Microbiol. 2012;14:52–66.
pubmed: 21895912 doi: 10.1111/j.1462-2920.2011.02555.x
Fu H, Jiang P, Zhao J, Wu C. Comparative genomics of Pseudomonas sp. strain SI-3 associated with macroalga Ulva prolifera, the causative species for green tide in the yellow sea. Front Microbiol. 2018;9:1458.
pubmed: 30013544 pmcid: 6036183 doi: 10.3389/fmicb.2018.01458
Kim J, Lyu XM, Lee JJL, Zhao G, Chin SF, Yang L, et al. Metabolomics analysis of Pseudomonas chlororaphis JK12 algicidal activity under aerobic and micro-aerobic culture condition. AMB Express. 2018;8:131.
pubmed: 30128639 pmcid: 6102160 doi: 10.1186/s13568-018-0660-x
Noh SY, Jung SW, Kim BH, Katano T, Han M-S. Algicidal activity of the bacterium, Pseudomonas fluorescens SK09, to mitigate Stephanodiscus hantzschii (Bacillariophyceae) blooms using field mesocosms. J Freshw Ecol. 2017;32:477–88.
doi: 10.1080/02705060.2017.1323682
Krug L, Morauf C, Donat C, Müller H, Cernava T, Berg G. Plant growth-promoting methylobacteria selectively increase the biomass of biotechnologically relevant microalgae. Front Microbiol. 2020;11:427.
pubmed: 32256478 pmcid: 7093331 doi: 10.3389/fmicb.2020.00427
Hopkinson BM, Morel FMM. The role of siderophores in iron acquisition by photosynthetic marine microorganisms. BioMetals. 2009;22:659–69.
pubmed: 19343508 doi: 10.1007/s10534-009-9235-2
Amin SA, Hmelo LR, van Tol HM, Durham BP, Carlson LT, Heal KR, et al. Interaction and signalling between a cosmopolitan phytoplankton and associated bacteria. Nature. 2015;522:98–101.
pubmed: 26017307 doi: 10.1038/nature14488
Amin SA, Green DH, Gärdes A, Romano A, Trimble L, Carrano CJ. Siderophore-mediated iron uptake in two clades of Marinobacter spp. associated with phytoplankton: the role of light. Bimetals 2012;25:181–92.
doi: 10.1007/s10534-011-9495-5
Amin SA, Green DH, Hart MC, Küpper FC, Sunda WG, Carrano CJ. Photolysis of iron-siderophore chelates promotes bacterial-algal mutualism. Proc Natl Acad Sci USA. 2009;106:17071–6.
pubmed: 19805106 pmcid: 2761308 doi: 10.1073/pnas.0905512106
Bajguz A, Piotrowska-Niczyporuk A. Interactive effect of brassinosteroids and cytokinins on growth, chlorophyll, monosaccharide and protein content in the green alga Chlorella vulgaris (Trebouxiophyceae). Plant Physiol Biochem. 2014;80:176–83.
pubmed: 24787502 doi: 10.1016/j.plaphy.2014.04.009
de-Bashan L, Antoun H, Bashan Y. Involvement of indole-3-acetic acid produced by the growth-promoting bacterium Azospirillum spp. In promoting growth of Chlorella vulgaris. J Phycol. 2008;44:938–47.
pubmed: 27041612 doi: 10.1111/j.1529-8817.2008.00533.x
Liu J, Qiu W, Song Y. Stimulatory effect of auxins on the growth and lipid productivity of Chlorella pyrenoidosa and Scenedesmus quadricauda. Algal Res. 2016;18:273–80.
doi: 10.1016/j.algal.2016.06.027
Ozioko FU, Chiejina NV, Ogbonna JC. Effect of some phytohormones on growth characteristics of Chlorella sorokiniana IAM-C212 under photoautotrophic conditions. Afr J Biotechnol. 2015;14:2367–76.
doi: 10.5897/AJB2015.14641
Yu Z, Song M, Pei H, Jiang L, Hou Q, Nie C, et al. The effects of combined agricultural phytohormones on the growth, carbon partitioning and cell morphology of two screened algae. Bioresour Technol. 2017;239:87–96.
pubmed: 28501687 doi: 10.1016/j.biortech.2017.04.120

Auteurs

Lisa Krug (L)

Institute of Environmental Biotechnology, Graz University of Technology, Petersgasse 12, 8010, Graz, Austria.
ACIB GmbH, Petersgasse 14, 8010, Graz, Austria.

Armin Erlacher (A)

Institute of Environmental Biotechnology, Graz University of Technology, Petersgasse 12, 8010, Graz, Austria.

Katharina Markut (K)

Institute of Environmental Biotechnology, Graz University of Technology, Petersgasse 12, 8010, Graz, Austria.

Gabriele Berg (G)

Institute of Environmental Biotechnology, Graz University of Technology, Petersgasse 12, 8010, Graz, Austria.

Tomislav Cernava (T)

Institute of Environmental Biotechnology, Graz University of Technology, Petersgasse 12, 8010, Graz, Austria. tomislav.cernava@tugraz.at.

Articles similaires

Populus Soil Microbiology Soil Microbiota Fungi
Aerosols Humans Decontamination Air Microbiology Masks
Coal Metagenome Phylogeny Bacteria Genome, Bacterial
Semiconductors Photosynthesis Polymers Carbon Dioxide Bacteria

Classifications MeSH