Changes in intraocular pressure, horizontal pupil diameter, and tear production during the use of topical 1% cyclopentolate in cats and rabbits.
Animals
Cat Diseases
/ drug therapy
Cats
Cyclopentolate
/ administration & dosage
Intraocular Pressure
/ drug effects
Lacrimal Apparatus Diseases
/ drug therapy
Mydriatics
/ administration & dosage
Ophthalmic Solutions
/ administration & dosage
Pupil
/ drug effects
Rabbits
Reference Values
Tears
/ drug effects
Tonometry, Ocular
/ veterinary
Cyclopentolate
Horizontal pupil diameter
Intraocular pressure
Tear production
Journal
Open veterinary journal
ISSN: 2218-6050
Titre abrégé: Open Vet J
Pays: Libya
ID NLM: 101653182
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
20
09
2019
accepted:
14
02
2020
entrez:
20
5
2020
pubmed:
20
5
2020
medline:
10
4
2021
Statut:
ppublish
Résumé
Cyclopentolate is not commonly used as mydriatic drug in veterinary medicine because of limited data on the local and systemic effects in animals. To determine the effects of topical 1% cyclopentolate hydrochloride on intraocular pressure (IOP), horizontal pupil diameter (HPD) and tear production in the cat and rabbit's eye during the first hour and up to 36 hours after treatment. One drop of 1% cyclopentolate hydrochloride was used in the left eye in 10 clinically and ophthalmologically healthy domestic cats and 10 rabbits. IOP and HPD were recorded every 5 minutes during the first hour, then every 2 hours during the following 12-hour period, and at 24 and 36 hours after application. Schirmer tear test (STT) was measured at 30 and 60 minute after treatment, then in same time points as IOP and HPD. Rebound tonometer (TonoVet 1% cyclopentolate increased IOP in cats, reaching a maximum (28.1 ± 5.4 mmHg) at Study showed novel data about the effects of 1% cyclopentolate to IOP, HPD, STT in cats and rabbits. Cyclopentolate in cats caused mydriasis 20-40 minutes after the treatment by increasing IOP, at the same time, pupil diameter reached pre-treatment values 24-36 hours after treatment. In rabbit's mydriasis occurred faster, 10-25 minutes after treatment without significant IOP increase and mydriasis lasted 10-12 hours. Significant STT decrease was recorded in cats, but more likely were connected to stress factors. This drug could be considered as a therapeutical alternative in rabbit more than in cats.
Sections du résumé
Background
Cyclopentolate is not commonly used as mydriatic drug in veterinary medicine because of limited data on the local and systemic effects in animals.
Aim
To determine the effects of topical 1% cyclopentolate hydrochloride on intraocular pressure (IOP), horizontal pupil diameter (HPD) and tear production in the cat and rabbit's eye during the first hour and up to 36 hours after treatment.
Methods
One drop of 1% cyclopentolate hydrochloride was used in the left eye in 10 clinically and ophthalmologically healthy domestic cats and 10 rabbits. IOP and HPD were recorded every 5 minutes during the first hour, then every 2 hours during the following 12-hour period, and at 24 and 36 hours after application. Schirmer tear test (STT) was measured at 30 and 60 minute after treatment, then in same time points as IOP and HPD. Rebound tonometer (TonoVet
Results
1% cyclopentolate increased IOP in cats, reaching a maximum (28.1 ± 5.4 mmHg) at
Conclusion
Study showed novel data about the effects of 1% cyclopentolate to IOP, HPD, STT in cats and rabbits. Cyclopentolate in cats caused mydriasis 20-40 minutes after the treatment by increasing IOP, at the same time, pupil diameter reached pre-treatment values 24-36 hours after treatment. In rabbit's mydriasis occurred faster, 10-25 minutes after treatment without significant IOP increase and mydriasis lasted 10-12 hours. Significant STT decrease was recorded in cats, but more likely were connected to stress factors. This drug could be considered as a therapeutical alternative in rabbit more than in cats.
Identifiants
pubmed: 32426258
doi: 10.4314/ovj.v10i1.10
pii: OVJ-10-59
pmc: PMC7193883
doi:
Substances chimiques
Mydriatics
0
Ophthalmic Solutions
0
Cyclopentolate
I76F4SHP7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-67Déclaration de conflit d'intérêts
None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of this paper.
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