Plasma Neprilysin Displays No Relevant Association With Neurohumoral Activation in Chronic HFrEF.
Aged
Biomarkers
/ blood
Cardiovascular Agents
/ therapeutic use
Chronic Disease
Female
Heart Failure
/ blood
Humans
Male
Middle Aged
Natriuretic Peptide, Brain
/ blood
Neprilysin
/ blood
Neurotransmitter Agents
/ blood
Norepinephrine
/ blood
Peptide Fragments
/ blood
Prognosis
Prospective Studies
Registries
Renin
/ blood
Severity of Illness Index
Stroke Volume
/ drug effects
Ventricular Function, Left
/ drug effects
biomarker
heart failure
neprilysin
neprilysin activity
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
02 06 2020
02 06 2020
Historique:
pubmed:
20
5
2020
medline:
11
3
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
Background Neprilysin is a transmembrane endopeptidase involved in the breakdown of a variety of vasoactive peptides and serves as a therapeutic target in heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate the relationship of circulating neprilysin with neurohumoral activation and the impact of plasma neprilysin activity on prognosis in HFrEF. Methods and Results A total of 369 chronic HFrEF patients were enrolled prospectively. Plasma neprilysin concentration and activity were determined by a specific ELISA and a fluorometric method. The association between plasma neprilysin and heart failure (HF) severity, neurohumoral activation, ie norepinephrine and absolute renin concentration, as well as all-cause mortality was assessed. Median plasma neprilysin concentrations and activity levels were 413 pg/mL (interquartile range 0-4111) and 2.36 nmol/mL per minute (interquartile range 1.16-4.59). No correlation could be shown between plasma neprilysin concentrations and activity (
Identifiants
pubmed: 32427034
doi: 10.1161/JAHA.119.015071
pmc: PMC7428996
doi:
Substances chimiques
Biomarkers
0
Cardiovascular Agents
0
Neurotransmitter Agents
0
Peptide Fragments
0
pro-brain natriuretic peptide (1-76)
0
Natriuretic Peptide, Brain
114471-18-0
Renin
EC 3.4.23.15
Neprilysin
EC 3.4.24.11
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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