Quantification of cylindrospermopsin, anatoxin-a and homoanatoxin-a in cyanobacterial bloom freshwater using direct injection/SPE coupled with UPLC-MS/MS.

Alkaloids Bacterial Toxins Bridged Bicyclo Compounds, Heterocyclic Chromatography, Liquid Cyanobacteria Toxins Fresh Water / analysis Microcystins Solid Phase Extraction Tandem Mass Spectrometry Tropanes Uracil / analogs & derivatives
Cyanotoxins Harmful algal blooms Hepatoxins Neurotoxins Occurrence

Journal

The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500

Informations de publication

Date de publication:
20 Aug 2020
Historique:
received: 12 02 2020
revised: 23 04 2020
accepted: 24 04 2020
pubmed: 20 5 2020
medline: 11 7 2020
entrez: 20 5 2020
Statut: ppublish

Résumé

Analytical methods based on direct injection (DI) and solid phase extraction (SPE) coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC- MS/MS) were developed for the determination of anatoxin-a (ATX-a), cylindrospermopsin (CYN), and homoanatoxin-a (HATX-a) in freshwater samples impacted with cyanobacterial blooms. The presence of CYN in freshwater samples was detected and quantified based on direct injection method, while ATX-a and HATX-a could be determined by both DI and SPE-based methods. Matrix effects (ME) on the signal intensity of the cyanotoxins were systematically evaluated for both direct injection and SPE extract samples. CYN, ATX-a, and HATX-a suffered a significant suppression during UPLC-MS/MS. The selection of internal standards (ISs) for compensating/correcting the losses of target cyanotoxins during sample preparation and matrix effects in UPLC-MS/MS analyses were systematically evaluated. Acetaminophen-d

Identifiants

DOI: 10.1016/j.scitotenv.2020.139014 PMID: 32428751
pubmed: 32428751
pii: S0048-9697(20)32531-6
doi: 10.1016/j.scitotenv.2020.139014
pii:
doi:

Substances chimiques

Alkaloids 0
Bacterial Toxins 0
Bridged Bicyclo Compounds, Heterocyclic 0
Cyanobacteria Toxins 0
Microcystins 0
Tropanes 0
homoanatoxin-a 0
cylindrospermopsin 2JIZ556BA3
Uracil 56HH86ZVCT
anatoxin a 80023A73NK

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

139014

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Ngoc Han Tran (NH)

Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam; NUS Environmental Research Institute, National University of Singapore, 1 Create Way, Create Tower, #15-02, Singapore 138602, Singapore.

Yiwen Li (Y)

Department of Environmental Science and Engineering, Sichuan University, China.

Martin Reinhard (M)

Department of Civil and Environmental Engineering, Stanford University, CA 94305, USA.

Kwan Chien Goh (KC)

NUS Environmental Research Institute, National University of Singapore, 1 Create Way, Create Tower, #15-02, Singapore 138602, Singapore.

Nur Hanisah Binte Sukarji (NHB)

NUS Environmental Research Institute, National University of Singapore, 1 Create Way, Create Tower, #15-02, Singapore 138602, Singapore.

Luhua You (L)

NUS Environmental Research Institute, National University of Singapore, 1 Create Way, Create Tower, #15-02, Singapore 138602, Singapore.

Yiliang He (Y)

School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Karina Yew-Hoong Gin (KY)

NUS Environmental Research Institute, National University of Singapore, 1 Create Way, Create Tower, #15-02, Singapore 138602, Singapore; Department of Civil and Environmental Engineering, National University of Singapore, 1 Engineering Drive 2, Singapore 117576, Singapore. Electronic address: ceeginyh@nus.edu.sg.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Composés hétérocycliques bicycliques › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Toxines de cyanobactéries › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Environnement et santé publique › Environnement › Eau douce › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Toxines de cyanobactéries › Microcystines › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Fractionnement chimique › Extraction en phase solide › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Tropanes › Quantification of cylindrospermopsin,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Uracile › Quantification of cylindrospermopsin,...