Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients.
EMAST
MSI
VEGF-B
combinatorial therapy
mCRC
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 May 2020
16 May 2020
Historique:
received:
24
04
2020
revised:
13
05
2020
accepted:
14
05
2020
entrez:
21
5
2020
pubmed:
21
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (
Identifiants
pubmed: 32429465
pii: ijms21103532
doi: 10.3390/ijms21103532
pmc: PMC7279028
pii:
doi:
Substances chimiques
VEGFB protein, human
0
Vascular Endothelial Growth Factor B
0
Bevacizumab
2S9ZZM9Q9V
Types de publication
Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Roche S.p.A. and the Italian Medicines Agency (AIFA)
ID : FARM6FJJAY
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