Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire tissue-resident memory like properties.
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Carcinoma, Squamous Cell
/ immunology
Cell Communication
Cell Movement
Cells, Cultured
Head and Neck Neoplasms
/ immunology
Humans
Immunologic Memory
Interleukin-15
/ metabolism
Interleukin-7
/ metabolism
Lymphocytes, Tumor-Infiltrating
/ immunology
Mesenchymal Stem Cells
/ immunology
Phenotype
Receptors, Notch
/ metabolism
Tumor Microenvironment
Vascular Cell Adhesion Molecule-1
/ metabolism
HNSCC
Stromal cells
T cells
Tissue-resident memory
VCAM1
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
15
01
2020
revised:
14
04
2020
pubmed:
23
5
2020
medline:
12
1
2021
entrez:
23
5
2020
Statut:
ppublish
Résumé
Tissue-resident memory (Trm) cells are specialized components of both CD4+ and CD8+ T cell subsets that persist in peripheral nonlymphoid tissues following infections and provide fast response in case of a secondary invasion by the same pathogen. Trm cells express the surface markers CD69, CD103, and the immune checkpoint molecule PD-1. Trm cells develop not only in the context of infections but also in tumors, where they can provide a line of defense as suggested by the positive correlation between the frequency of tumor-infiltrating Trm cells and patients' survival. Trm cells persistence in peripheral tissues depends on their adaptation to the local microenvironment and the presence of survival factors, mainly IL-7, IL-15, and Notch ligands. However, the cell sources of these factors are largely unknown, especially in the context of tumors. Here, we show that head-neck squamous cell carcinoma (HNSCC) is enriched in CD4+ and CD8+ T cells with a Trm phenotype. Moreover, we show that mesenchymal stromal cells that accumulate in HNSCC are a source of survival factors and allow proper expression of Trm-typical markers in a VCAM1-dependent manner.
Identifiants
pubmed: 32441311
doi: 10.1002/eji.202048544
doi:
Substances chimiques
Interleukin-15
0
Interleukin-7
0
Receptors, Notch
0
Vascular Cell Adhesion Molecule-1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1571-1579Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
Pays : International
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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