Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin.
Acute Lung Injury
/ etiology
Anti-Inflammatory Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
Betacoronavirus
COVID-19
Coronavirus Infections
/ complications
Drug Therapy, Combination
Escin
/ administration & dosage
Humans
Immunologic Factors
/ therapeutic use
Inflammation Mediators
/ metabolism
Lung
/ pathology
Pandemics
Pneumonia, Viral
/ complications
SARS-CoV-2
COVID-19
acute lung injury
coronavirus-2
escin
pneumonia
Journal
Journal of clinical pharmacology
ISSN: 1552-4604
Titre abrégé: J Clin Pharmacol
Pays: England
ID NLM: 0366372
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
15
04
2020
accepted:
22
04
2020
pubmed:
23
5
2020
medline:
7
7
2020
entrez:
23
5
2020
Statut:
ppublish
Résumé
Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that induce intra-alveolar fibrin accumulation that reduces the gas exchange. Therefore, an add-on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). In this article reviewing literature data related to the use of escin, an agent having potent anti-inflammatory and anti-viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add-on therapy in ALI related to COVID-19 infection.
Identifiants
pubmed: 32441805
doi: 10.1002/jcph.1644
pmc: PMC7280635
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antiviral Agents
0
Immunologic Factors
0
Inflammation Mediators
0
Escin
6805-41-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
815-825Informations de copyright
© 2020, The American College of Clinical Pharmacology.
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