Plasma Oxalate as a Predictor of Kidney Function Decline in a Primary Hyperoxaluria Cohort.
Urine Oxalate
chronic kidney disease
end-stage renal disease
estimated glomerular filtration rate
plasma oxalate
primary hyperoxaluria
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 May 2020
20 May 2020
Historique:
received:
01
04
2020
revised:
15
05
2020
accepted:
16
05
2020
entrez:
24
5
2020
pubmed:
24
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
This retrospective analysis investigated plasma oxalate (POx) as a potential predictor of end-stage kidney disease (ESKD) among primary hyperoxaluria (PH) patients. PH patients with type 1, 2, and 3, age 2 or older, were identified in the Rare Kidney Stone Consortium (RKSC) PH Registry. Since POx increased with falling estimated glomerular filtration rate (eGFR), patients were stratified by chronic kidney disease (CKD) subgroups (stages 1, 2, 3a, and 3b). POx values were categorized into quartiles for analysis. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for risk of ESKD were estimated using the Cox proportional hazards model with a time-dependent covariate. There were 118 patients in the CKD1 group (nine ESKD events during follow-up), 135 in the CKD 2 (29 events), 72 in CKD3a (34 events), and 45 patients in CKD 3b (31 events). During follow-up, POx Q4 was a significant predictor of ESKD compared to Q1 across CKD2 (HR 14.2, 95% CI 1.8-115), 3a (HR 13.7, 95% CI 3.0-62), and 3b stages (HR 5.2, 95% CI 1.1-25),
Identifiants
pubmed: 32443777
pii: ijms21103608
doi: 10.3390/ijms21103608
pmc: PMC7279271
pii:
doi:
Substances chimiques
Biomarkers
0
Oxalates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : R21 TR003174
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54DK083908
Pays : United States
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