Variability in electrophysiological properties and conducting obstacles controls re-entry risk in heterogeneous ischaemic tissue.
cardiac electrophysiology
fibrosis
ischaemia
mathematical modelling
statistics
Journal
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
ISSN: 1471-2962
Titre abrégé: Philos Trans A Math Phys Eng Sci
Pays: England
ID NLM: 101133385
Informations de publication
Date de publication:
12 Jun 2020
12 Jun 2020
Historique:
entrez:
26
5
2020
pubmed:
26
5
2020
medline:
2
3
2021
Statut:
ppublish
Résumé
Ischaemia, in which inadequate blood supply compromises and eventually kills regions of cardiac tissue, can cause many types of arrhythmia, some life-threatening. A significant component of this is the effects of the resulting hypoxia, and concomitant hyperklaemia and acidosis, on the electrophysiological properties of myocytes. Clinical and experimental data have also shown that regions of structural heterogeneity (fibrosis, necrosis, fibro-fatty infiltration) can act as triggers for arrhythmias under acute ischaemic conditions. Mechanistic models have successfully captured these effects
Identifiants
pubmed: 32448068
doi: 10.1098/rsta.2019.0341
pmc: PMC7287337
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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