Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model.
Animals
Apoptosis
Biomarkers, Tumor
/ analysis
CD8-Positive T-Lymphocytes
/ immunology
Cell Proliferation
Disease Models, Animal
Humans
Immunosuppression Therapy
Interferon Regulatory Factors
/ physiology
Mice
Mice, Knockout
Myeloid-Derived Suppressor Cells
/ immunology
Pancreatic Neoplasms
/ immunology
Prognosis
Survival Rate
Tumor Cells, Cultured
Tumor Microenvironment
/ immunology
IRF4
Immunosuppression
Myeloid-derived suppressor cells (MDSC)
Myelopoiesis
Pancreatic cancer
Journal
Cancer immunology, immunotherapy : CII
ISSN: 1432-0851
Titre abrégé: Cancer Immunol Immunother
Pays: Germany
ID NLM: 8605732
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
31
12
2019
accepted:
12
05
2020
pubmed:
26
5
2020
medline:
7
10
2020
entrez:
26
5
2020
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma is characterized by a strong immunosuppressive network with a dense infiltration of myeloid cells including myeloid-derived suppressor cells (MDSC). Two distinct populations of MDSC have been defined: polymorphonuclear MDSC (PMN-MDSC) and monocytic MDSC (M-MDSC). Several factors influence the development and function of MDSC including the transcription factor interferon regulatory factor 4 (IRF4). Here, we show that IRF4 deficiency accelerates tumor growth and reduces survival, accompanied with a dense tumor infiltration with PMN-MDSC and reduced numbers of CD8
Identifiants
pubmed: 32448983
doi: 10.1007/s00262-020-02605-9
pii: 10.1007/s00262-020-02605-9
pmc: PMC7511276
doi:
Substances chimiques
Biomarkers, Tumor
0
Interferon Regulatory Factors
0
interferon regulatory factor-4
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2101-2112Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 315563603
Organisme : Deutsche Forschungsgemeinschaft
ID : 329628492
Organisme : Deutsche Forschungsgemeinschaft
ID : 238187445
Organisme : Deutsche Forschungsgemeinschaft
ID : 385829722
Organisme : Deutsche Forschungsgemeinschaft
ID : 405344257
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 641549
Organisme : Narodowym Centrum Nauki (PL)
ID : 2016/23/B/NZ6/00086
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