Cholinergic Modulation of Binocular Vision.
Acetylcholine
/ pharmacology
Adult
Cholinergic Agents
/ pharmacology
Cholinesterase Inhibitors
/ pharmacology
Cross-Over Studies
Donepezil
/ pharmacology
Female
Functional Laterality
/ drug effects
Humans
Male
Parasympathetic Nervous System
/ drug effects
Photic Stimulation
Psychomotor Performance
/ drug effects
Vision Disparity
Vision, Binocular
/ drug effects
Young Adult
gamma-Aminobutyric Acid
/ physiology
acetylcholinesterase inhibitors
binocular rivalry
binocular vision
cholinergic modulation
excitatory/inhibitory balance
visual cortex
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
14
10
2019
revised:
12
05
2020
accepted:
14
05
2020
pubmed:
28
5
2020
medline:
24
11
2020
entrez:
28
5
2020
Statut:
ppublish
Résumé
The endogenous neurotransmitter acetylcholine (ACh) is known to affect the excitatory/inhibitory (E/I) balance of primate visual cortex, enhancing feedforward thalamocortical gain while suppressing corticocortical synapses. Recent advances in the study of the human visual system suggest that ACh is a likely component underlying interocular interactions. However, our understanding of its precise role in binocular processes is currently lacking. Here we use binocular rivalry as a probe of interocular dynamics to determine ACh's effects, via the acetylcholinesterase inhibitor (AChEI) donepezil, on the binocular visual system. A total of 23 subjects (13 male) completed two crossover experimental sessions where binocular rivalry measurements were obtained before and after taking either donepezil (5 mg) or a placebo (lactose) pill. We report that enhanced cholinergic potentiation attenuates perceptual suppression during binocular rivalry, reducing the overall rate of interocular competition while enhancing the visibility of superimposition mixed percepts. Considering recent evidence that perceptual suppression during binocular rivalry is causally modulated by the inhibitory neurotransmitter GABA, our results suggest that cholinergic activity counteracts the effect of GABA with regards to interocular dynamics and may modulate the inhibitory drive within the visual cortex.
Identifiants
pubmed: 32457075
pii: JNEUROSCI.2484-19.2020
doi: 10.1523/JNEUROSCI.2484-19.2020
pmc: PMC7329301
doi:
Substances chimiques
Cholinergic Agents
0
Cholinesterase Inhibitors
0
gamma-Aminobutyric Acid
56-12-2
Donepezil
8SSC91326P
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5208-5213Subventions
Organisme : CIHR
ID : 148579
Pays : Canada
Organisme : CIHR
ID : MOP-111003
Pays : Canada
Informations de copyright
Copyright © 2020 the authors.
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