The serum angiotensin-converting enzyme 2 and angiotensin-(1-7) concentrations after optimal therapy for acute decompensated heart failure with reduced ejection fraction.
acute heart failure
angiotensin converting enzyme 2
angiotensin-(1-7)
optimal therapy
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
03
08
2019
revised:
26
05
2020
accepted:
26
05
2020
pubmed:
28
5
2020
medline:
25
3
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
Elucidation of the role of angiotensin-converting enzyme (ACE) 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis in heart failure is necessary. No previous study has reported serial changes in ACE2 and Ang-(1-7) concentrations after optimal therapy (OT) in acute heart failure (AHF) patients. We aimed to investigate serial changes in serum ACE2 and Ang-(1-7) concentrations after OT in AHF patients with reduced ejection fraction (EF). ACE2 and Ang-(1-7) concentrations were measured in 68 AHF patients with reduced EF immediately after admission and 1 and 3 months after OT. These parameters were compared with the healthy individuals at three time points. In the acute phase, Ang-(1-7) and ACE2 concentrations was statistically significantly lower and higher in AHF patients than the healthy individuals (2.40 ± 1.11 vs. 3.1 ± 1.1 ng/ml, P<0.005 and 7.45 ± 3.13 vs. 4.84 ± 2.25 ng/ml, P<0.005), respectively. At 1 month after OT, Ang-(1-7) concentration remained lower in AHF patients than the healthy individuals (2.37 ± 1.63 vs. 3.1 ± 1.1 ng/ml, P<0.05); however, there was no statistically significant difference in ACE2 concentration between AHF patients and the healthy individuals. At 3 months after OT, there were no statistically significant differences in Ang-(1-7) and ACE2 concentrations between AHF patients and the healthy individuals. ACE2 concentration was equivalent between AHF patients and the healthy individuals at 1 and 3 months after OT, and Ang-(1-7) concentration was equivalent at 3 months after OT.
Identifiants
pubmed: 32458985
pii: 225014
doi: 10.1042/BSR20192701
pmc: PMC7295637
pii:
doi:
Substances chimiques
Biomarkers
0
Peptide Fragments
0
Angiotensin I
9041-90-1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
angiotensin I (1-7)
IJ3FUK8MOF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 The Author(s).
Références
Hypertension. 2001 Jul;38(1):90-4
pubmed: 11463766
Circ J. 2013;77(8):2157-201
pubmed: 23759659
Horm Metab Res. 1998 Aug;30(8):490-5
pubmed: 9761377
N Engl J Med. 2020 May 1;:
pubmed: 32356626
J Endocrinol. 1981 Dec;91(3):457-65
pubmed: 7035596
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
Circulation. 1996 Aug 15;94(4):690-7
pubmed: 8772689
J Hypertens. 2001 Mar;19(3 Pt 2):635-9
pubmed: 11327640
Nat Rev Cardiol. 2020 May;17(5):259-260
pubmed: 32139904
Circulation. 2003 Feb 18;107(6):807-10
pubmed: 12591748
Heart Vessels. 2017 Mar;32(3):303-308
pubmed: 27421979
Proc Natl Acad Sci U S A. 1988 Jun;85(11):4095-8
pubmed: 3375255
Hypertens Res. 2011 Feb;34(2):154-60
pubmed: 21124322
Clin Sci (Lond). 2012 Aug 1;123(4):193-203
pubmed: 22548405
Circulation. 2007 Apr 3;115(13):1754-61
pubmed: 17372171
N Engl J Med. 1991 Aug 1;325(5):293-302
pubmed: 2057034
N Engl J Med. 1987 Jun 4;316(23):1429-35
pubmed: 2883575
Cardiovasc Drugs Ther. 1995 Feb;9(1):145-9
pubmed: 7786835
Cardiovasc Drugs Ther. 2018 Apr;32(2):213-222
pubmed: 29679303
Nature. 2002 Jun 20;417(6891):822-8
pubmed: 12075344
Eur J Heart Fail. 2014 Jul;16(7):817-25
pubmed: 24828035
J Biol Chem. 2002 Apr 26;277(17):14838-43
pubmed: 11815627
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8258-63
pubmed: 12829792
J Am Coll Cardiol. 2019 Apr 23;73(15):1931-1944
pubmed: 30999996
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Circulation. 2001 Jan 2;103(1):72-7
pubmed: 11136688
Hypertension. 2010 Feb;55(2):207-13
pubmed: 20038757
Circulation. 2003 Sep 16;108(11):1306-9
pubmed: 12939207
Hypertension. 2006 Apr;47(4):718-26
pubmed: 16505206
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Exp Physiol. 2008 May;93(5):519-27
pubmed: 18310257
Circulation. 2003 Oct 7;108(14):1707-12
pubmed: 14504186
N Engl J Med. 1971 Dec 23;285(26):1441-6
pubmed: 5122894
N Engl J Med. 2020 Apr 23;382(17):1653-1659
pubmed: 32227760
J Am Coll Cardiol. 2008 Aug 26;52(9):755-7
pubmed: 18718424