Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam.
COVID-19
SARS-CoV-2
Vero
complete genome sequencing
coronavirus
respiratory infections
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
30
04
2020
revised:
25
05
2020
accepted:
26
05
2020
pubmed:
29
5
2020
medline:
30
12
2020
entrez:
29
5
2020
Statut:
ppublish
Résumé
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.
Identifiants
pubmed: 32462705
doi: 10.1002/jmv.26075
pmc: PMC7283826
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2209-2215Subventions
Organisme : Vietnam's Ministry of Science and Technology
ID : 32/20-ÐTÐL.CN-CNN
Pays : International
Informations de copyright
© 2020 Wiley Periodicals LLC.
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