Neurobiological influence of comorbid conditions in young patients diagnosed with gaming disorder: A whole-brain functional connectivity study based on a data driven method.
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity
/ complications
Autism Spectrum Disorder
/ complications
Behavior, Addictive
/ physiopathology
Brain
/ physiopathology
Brain Mapping
/ methods
Cognition
Emotions
Executive Function
Gambling
/ complications
Humans
Male
Neural Pathways
/ physiopathology
Reward
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
11
2019
accepted:
12
05
2020
entrez:
30
5
2020
pubmed:
30
5
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Gaming disorder, which is characterized by multiple cognitive and behavioral symptoms, often has comorbid psychiatric conditions such as depression and attention-deficit hyperactivity disorder. Neurobiological effects of the comorbid disorders so far reported are not converging, exhibiting positive and negative alterations of the connectivity in brain networks. In this study, we conducted resting-state functional magnetic-resonance imaging and whole brain functional connectivity analyses for young participants consisting of 40 patients diagnosed with the gaming disorder, with and without comorbid conditions, and 29 healthy controls. Compared to healthy controls, the gaming disorder-alone patients had partially diminished connectivities in the reward system and executive control network, within which there existed central nodes that served as a hub of diminished connections. In the gaming disorder patients who had comorbidity of autism spectrum disorder, the diminished connections were enlarged, with alteration of the hub nodes, to the entire brain areas involved in the reward system including cortical, subcortical and limbic areas that are crucial for reward processing, and to the whole cortical areas composing the executive control network. These observations suggest that the neurodevelopmental condition coexisting with the gaming disorder induced substantial impairment of the neural organizations associated with executive/cognitive and emotional functions, which are plausibly causal to the behavioral addiction, by rearranging and diminishing functional connectivities in the network.
Identifiants
pubmed: 32469991
doi: 10.1371/journal.pone.0233780
pii: PONE-D-19-32315
pmc: PMC7259694
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0233780Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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