Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide.


Journal

HLA
ISSN: 2059-2310
Titre abrégé: HLA
Pays: England
ID NLM: 101675570

Informations de publication

Date de publication:
09 2020
Historique:
received: 15 05 2020
revised: 19 05 2020
accepted: 26 05 2020
pubmed: 1 6 2020
medline: 2 9 2020
entrez: 1 6 2020
Statut: ppublish

Résumé

We report detailed peptide-binding affinities between 438 HLA Class I and Class II proteins and complete proteomes of seven pandemic human viruses, including coronaviruses, influenza viruses and HIV-1. We contrast these affinities with HLA allele frequencies across hundreds of human populations worldwide. Statistical modelling shows that peptide-binding affinities classified into four distinct categories depend on the HLA locus but that the type of virus is only a weak predictor, except in the case of HIV-1. Among the strong HLA binders (IC

Identifiants

pubmed: 32475052
doi: 10.1111/tan.13956
pmc: PMC7300650
doi:

Substances chimiques

HLA Antigens 0
Peptides 0
Viral Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

277-298

Subventions

Organisme : Australian Government Research Training Program Stipend (RTPS)
Pays : International
Organisme : Australian Research Council Discovery Indigenous Project
ID : IN180100017
Pays : International
Organisme : Australian Research Council Future Fellowship
ID : FT170100448
Pays : International
Organisme : European Cooperation in Science and Technology
ID : BM0803
Pays : International
Organisme : Max-Planck-Gesellschaft
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 310030_188820
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 31003A_144180
Pays : International

Informations de copyright

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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Auteurs

Rodrigo Barquera (R)

Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.

Evelyn Collen (E)

Australian Centre for Ancient DNA (ACAD), Department of Genetics and Evolution, The University of Adelaide, Adelaide, South Australia, Australia.

Da Di (D)

Anthropology Unit, Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.

Stéphane Buhler (S)

Anthropology Unit, Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland.

João Teixeira (J)

Australian Centre for Ancient DNA (ACAD), Department of Genetics and Evolution, The University of Adelaide, Adelaide, South Australia, Australia.
School of Biological Sciences, Centre of Excellence for Australian Biodiversity and Heritage, The University of Adelaide, Adelaide, South Australia, Australia.

Bastien Llamas (B)

School of Biological Sciences, Centre of Excellence for Australian Biodiversity and Heritage, The University of Adelaide, Adelaide, South Australia, Australia.
The Environment Institute, The University of Adelaide, Adelaide, South Australia, Australia.

José M Nunes (JM)

Anthropology Unit, Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva, Geneva, Switzerland.

Alicia Sanchez-Mazas (A)

Anthropology Unit, Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva, Geneva, Switzerland.

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Classifications MeSH