Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance.
Animals
Antigens
/ immunology
Autoantibodies
/ metabolism
Female
Fetus
/ immunology
Histocompatibility Antigens Class I
/ metabolism
Humans
Immune System
/ embryology
Immune Tolerance
Immunoglobulin G
/ metabolism
Maternal-Fetal Exchange
/ immunology
Mice
Placenta
/ immunology
Pregnancy
Protein Transport
/ immunology
Receptors, Fc
/ metabolism
Transcytosis
/ immunology
hemophilia A
immune system ontogeny
immune tolerance induction
maternal IgG
neonatal Fc receptor (FcRn)
therapy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
01
2020
accepted:
08
04
2020
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
16
3
2021
Statut:
epublish
Résumé
In humans, maternal IgGs are transferred to the fetus from the second trimester of pregnancy onwards. The transplacental delivery of maternal IgG is mediated by its binding to the neonatal Fc receptor (FcRn) after endocytosis by the syncytiotrophoblast. IgGs present in the maternal milk are also transferred to the newborn through the digestive epithelium upon binding to the FcRn. Importantly, the binding of IgGs to the FcRn is also responsible for the recycling of circulating IgGs that confers them with a long half-life. Maternally delivered IgG provides passive immunity to the newborn, for instance by conferring protective anti-flu or anti-pertussis toxin IgGs. It may, however, lead to the development of autoimmune manifestations when pathological autoantibodies from the mother cross the placenta and reach the circulation of the fetus. In recent years, strategies that exploit the transplacental delivery of antigen/IgG complexes or of Fc-fused proteins have been validated in mouse models of human diseases to impose antigen-specific tolerance, particularly in the case of Fc-fused factor VIII (FVIII) domains in hemophilia A mice or pre-pro-insulin (PPI) in the case of preclinical models of type 1 diabetes (T1D). The present review summarizes the mechanisms underlying the FcRn-mediated transcytosis of IgGs, the physiopathological relevance of this phenomenon, and the repercussion for drug delivery and shaping of the immune system during its ontogeny.
Identifiants
pubmed: 32477339
doi: 10.3389/fimmu.2020.00810
pmc: PMC7240014
doi:
Substances chimiques
Antigens
0
Autoantibodies
0
Histocompatibility Antigens Class I
0
Immunoglobulin G
0
Receptors, Fc
0
Fc receptor, neonatal
TW3XAW0RCY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
810Informations de copyright
Copyright © 2020 Mimoun, Delignat, Peyron, Daventure, Lecerf, Dimitrov, Kaveri, Bayry and Lacroix-Desmazes.
Références
Clin Dev Immunol. 2012;2012:985646
pubmed: 22235228
Eur J Immunol. 1994 Mar;24(3):542-8
pubmed: 8125126
Mol Immunol. 2018 Mar;95:1-9
pubmed: 29367080
Expert Opin Pharmacother. 2006 Feb;7(3):325-43
pubmed: 16448327
J Exp Med. 1981 Jan 1;153(1):154-65
pubmed: 6969781
Nature. 1994 Nov 24;372(6504):336-43
pubmed: 7969491
J Immunol. 2003 Apr 1;170(7):3528-33
pubmed: 12646614
Clin Exp Allergy. 1996 Jun;26(6):621-3
pubmed: 8809418
Biochemistry. 2000 Aug 15;39(32):9698-708
pubmed: 10933786
MAbs. 2018 Oct;10(7):1111-1130
pubmed: 30130439
J Reprod Immunol. 1983 Jul;5(4):203-13
pubmed: 6620251
Blood. 2005 Nov 1;106(9):3004-11
pubmed: 16020514
Lancet. 1954 May 8;266(6819):964-5
pubmed: 13164306
Arthritis Res Ther. 2003;5(6):266-70
pubmed: 14680501
J Immunol. 1995 Jun 15;154(12):6246-51
pubmed: 7759862
J Allergy Clin Immunol. 2001 Nov;108(5):709-14
pubmed: 11692093
J Immunol. 2010 Feb 15;184(4):2148-55
pubmed: 20089705
Mol Cell. 2001 Apr;7(4):867-77
pubmed: 11336709
Acta Paediatr. 2012 Feb;101(2):120-7
pubmed: 22003882
Nat Rev Drug Discov. 2008 Nov;7(11):887-8
pubmed: 18974747
Ann N Y Acad Sci. 1995 Dec 29;770:8-33
pubmed: 8597385
Nat Med. 2008 Feb;14(2):170-5
pubmed: 18223654
Sci Rep. 2018 Oct 2;8(1):14648
pubmed: 30279529
Home Healthc Now. 2015 Oct;33(9):487-92
pubmed: 26418108
Crit Rev Biotechnol. 2015 Jun;35(2):235-54
pubmed: 24156398
Histochem Cell Biol. 2007 Sep;128(3):205-15
pubmed: 17624541
Immunology. 1996 Dec;89(4):573-8
pubmed: 9014824
Pharmacol Res. 2020 Apr;154:104168
pubmed: 30738127
J Perinat Med. 2003;31(6):535-7
pubmed: 14711113
Clin Exp Allergy. 2015 Jun;45(6):1085-98
pubmed: 25652137
J Clin Invest. 1945 Jan;24(1):46-53
pubmed: 16695187
J Cell Biol. 1980 Apr;85(1):18-32
pubmed: 7364873
J Cell Biol. 1990 Nov;111(5 Pt 1):1867-76
pubmed: 2146275
Pediatr Blood Cancer. 2005 Aug;45(2):176-83
pubmed: 15828027
J Exp Med. 2009 Aug 3;206(8):1661-71
pubmed: 19635858
J Immunol. 2004 Feb 15;172(4):2021-9
pubmed: 14764666
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42
pubmed: 18599440
Nature. 1999 Nov 25;402(6760 Suppl):B12-7
pubmed: 10586890
Semin Fetal Neonatal Med. 2008 Aug;13(4):207-14
pubmed: 18396474
Pediatrics. 2015 Jun;135(6):e1475-82
pubmed: 25963002
Mucosal Immunol. 2010 Sep;3(5):461-74
pubmed: 20485331
Nature. 1989 Jan 12;337(6203):184-7
pubmed: 2911353
J Immunol. 1999 Dec 15;163(12):6511-9
pubmed: 10586043
Lancet. 1992 Jul 25;340(8813):253
pubmed: 1353186
Nat Rev Immunol. 2013 Mar;13(3):176-89
pubmed: 23411799
Int Immunol. 1995 Apr;7(4):645-52
pubmed: 7547692
Arthritis Res Ther. 2015 May 20;17:135
pubmed: 25994180
J Immunol. 2009 Mar 1;182(5):2583-9
pubmed: 19234152
Cell. 2000 Jan 7;100(1):157-68
pubmed: 10647940
Diabetes. 2015 Oct;64(10):3532-42
pubmed: 25918233
J Cell Biol. 1981 Oct;91(1):270-80
pubmed: 7298722
MAbs. 2019 Oct;11(7):1276-1288
pubmed: 31216930
Diabetes. 2005 Jan;54(1):251-8
pubmed: 15616036
Ann Intern Med. 1994 Apr 1;120(7):544-51
pubmed: 8116991
Immunity. 2004 Jun;20(6):769-83
pubmed: 15189741
J Immunol. 1989 Jan 1;142(1):57-66
pubmed: 2783327
Histochem J. 1991 Oct;23(10):444-9
pubmed: 1743992
Lancet. 2001 Oct 6;358(9288):1129-33
pubmed: 11597666
Immunol Today. 1989 Mar;10(3):87-91
pubmed: 2472811
PLoS Biol. 2004 Mar;2(3):E75
pubmed: 15024423
Blood. 2014 Dec 11;124(25):3709-18
pubmed: 25352126
Nat Biotechnol. 2005 Oct;23(10):1283-8
pubmed: 16186811
J Allergy Clin Immunol. 2011 Mar;127(3):823-30.e1-7
pubmed: 21281961
J Immunol. 1996 Oct 15;157(8):3317-22
pubmed: 8871627
J Allergy Clin Immunol. 2009 Oct;124(4):639-46; quiz 647-8
pubmed: 19815110
Rheumatology (Oxford). 2012 Jun;51(6):1086-92
pubmed: 22308531
Scand J Immunol. 1994 Oct;40(4):457-65
pubmed: 7939418
EMBO J. 2000 Jun 1;19(11):2465-74
pubmed: 10835345
Drug Metab Dispos. 2011 Sep;39(9):1469-77
pubmed: 21610128
J Mol Med (Berl). 2004 Apr;82(4):232-9
pubmed: 15168680
Eur J Immunol. 1994 Oct;24(10):2429-34
pubmed: 7925571
Indian J Biochem Biophys. 1999 Aug;36(4):252-7
pubmed: 10650727
J Infect Dis. 1995 Jan;171(1):99-105
pubmed: 7798688
Front Immunol. 2014 Oct 20;5:520
pubmed: 25368619
Front Immunol. 2018 Apr 30;9:880
pubmed: 29760702
Sci Transl Med. 2017 Nov 1;9(414):
pubmed: 29093180
J Clin Invest. 2006 Aug;116(8):2142-2151
pubmed: 16841095
Int Arch Allergy Immunol. 2000 Sep;123(1):46-57
pubmed: 11014971
Cell. 1997 Sep 19;90(6):1073-83
pubmed: 9323135
J Autoimmun. 2010 Nov;35(3):219-24
pubmed: 20685080
Proc R Soc Lond B Biol Sci. 1955 Nov 29;144(916):427-30
pubmed: 13280691
J Immunol. 2013 May 1;190(9):4535-41
pubmed: 23526819
J Clin Invest. 2018 Oct 1;128(10):4372-4386
pubmed: 30040076
Semin Thromb Hemost. 2018 Sep;44(6):517-530
pubmed: 29864775
Eur J Immunogenet. 2000 Aug;27(4):231-40
pubmed: 10998088
Int Immunol. 1998 Sep;10(9):1289-98
pubmed: 9786428
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1913-6
pubmed: 2308952
Sci Rep. 2016 Sep 26;6:34001
pubmed: 27666402
Int Immunol. 2003 Feb;15(2):187-95
pubmed: 12578848
Eur J Immunol. 1985 Jul;15(7):733-8
pubmed: 2988974
Clin Rev Allergy Immunol. 2011 Feb;40(1):27-41
pubmed: 20012231
Clin Exp Allergy. 2008 Dec;38(12):1950-8
pubmed: 18778271
Semin Immunol. 2008 Jun;20(3):164-70
pubmed: 18424165
J Infect Dis. 1990 Mar;161(3):487-92
pubmed: 2313127
Nature. 1994 Nov 24;372(6504):379-83
pubmed: 7969498
Early Hum Dev. 2011 Feb;87(2):67-72
pubmed: 21123010
Cell. 2019 Jun 27;178(1):202-215.e14
pubmed: 31204102
Front Immunol. 2018 Jul 30;9:1759
pubmed: 30105028
Nature. 2008 Sep 25;455(7212):542-6
pubmed: 18818657
Nat Biotechnol. 2010 Feb;28(2):157-9
pubmed: 20081867
Am J Physiol Renal Physiol. 2002 Feb;282(2):F358-65
pubmed: 11788451
Nat Rev Immunol. 2003 Apr;3(4):292-303
pubmed: 12669020
Pediatr Res. 1997 Jan;41(1):128-31
pubmed: 8979301
Ann Neurol. 2004 Apr;55(4):495-502
pubmed: 15048888
MAbs. 2018 Jan;10(1):81-94
pubmed: 28991504
Biochim Biophys Acta. 2005 Jan 11;1681(2-3):88-98
pubmed: 15627500
Nat Commun. 2011 Dec 20;2:599
pubmed: 22186895
J Allergy Clin Immunol. 2019 Aug;144(2):524-535.e8
pubmed: 30529242
Immunology. 2007 Sep;122(1):107-15
pubmed: 17608811
J Exp Med. 2005 Jan 3;201(1):11-7
pubmed: 15630133
J Anat. 2001 Feb;198(Pt 2):189-205
pubmed: 11273044
Eur J Immunol. 1999 Sep;29(9):2819-25
pubmed: 10508256
Thromb Res. 2009 Dec;124 Suppl 2:S6-8
pubmed: 20109653
J Cell Sci. 2000 Apr;113 ( Pt 7):1277-85
pubmed: 10704378
Clin Exp Immunol. 1990 Oct;82(1):114-9
pubmed: 2119917
Eur J Immunol. 1999 Aug;29(8):2515-23
pubmed: 10458766
Hum Immunol. 2005 Apr;66(4):403-10
pubmed: 15866704
Blood. 2013 May 23;121(21):e118-28
pubmed: 23525796
Placenta. 2019 Mar;78:36-43
pubmed: 30955709
J Immunol. 1997 Mar 1;158(5):2211-7
pubmed: 9036967
J Immunol. 1998 Nov 1;161(9):5061-9
pubmed: 9794444
J Cell Biol. 1973 Jul;58(1):189-211
pubmed: 4726306
Clin Pharmacol Ther. 2019 Apr;105(4):1031-1039
pubmed: 30402880
J Histochem Cytochem. 2017 Jun;65(6):321-333
pubmed: 28402755
J Exp Med. 2018 Jan 2;215(1):1-3
pubmed: 29196507
Ann Rheum Dis. 2015 Nov;74(11):1983-9
pubmed: 24938285
Ann Rheum Dis. 2009 Jun;68(6):828-35
pubmed: 18625627
Placenta. 2009 Apr;30(4):329-34
pubmed: 19215981
Cell Metab. 2018 Dec 4;28(6):946-960.e6
pubmed: 30078552
Eur J Immunol. 1996 Jul;26(7):1527-31
pubmed: 8766556
J Clin Invest. 1999 Oct;104(7):903-11
pubmed: 10510331
Blood. 2013 Aug 15;122(7):1174-81
pubmed: 23843496
Pediatr Res. 2000 Sep;48(3):404-7
pubmed: 10960510
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6416-20
pubmed: 7031652
Sci Transl Med. 2015 Feb 18;7(275):275ra21
pubmed: 25696000
Am J Reprod Immunol. 1996 Nov;36(5):248-55
pubmed: 8955500
Blood. 2010 Mar 11;115(10):2057-64
pubmed: 20056791
Blood. 2012 Mar 29;119(13):3024-30
pubmed: 22246033
J Biol Chem. 2001 Mar 2;276(9):6591-604
pubmed: 11096108
Cell Mol Life Sci. 2013 Apr;70(8):1319-34
pubmed: 22847331
J Exp Med. 1994 Dec 1;180(6):2377-81
pubmed: 7964511
Semin Neonatol. 2002 Feb;7(1):75-83
pubmed: 12069540
Sci Rep. 2016 Dec 09;6:38874
pubmed: 27934956
Clin Ther. 1999 Jan;21(1):75-87; discussion 1-2
pubmed: 10090426
J Immunol. 2009 Jun 15;182(12):7527-38
pubmed: 19494276
Vaccine. 2003 Jul 28;21(24):3365-9
pubmed: 12850341
Clin Infect Dis. 2010 Dec 15;51(12):1355-61
pubmed: 21058908
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11076-81
pubmed: 15258288
Eur J Immunol. 1996 Jul;26(7):1668-71
pubmed: 8766579
Science. 1974 Nov 15;186(4164):643-4
pubmed: 4137580
Semin Immunol. 2002 Dec;14(6):361-9
pubmed: 12457608
Int Immunol. 2001 Dec;13(12):1551-9
pubmed: 11717196
J Immunol. 1993 Dec 1;151(11):6076-88
pubmed: 7504013
Nature. 1964 Sep 26;203:1352-4
pubmed: 14207307
Arthritis Rheum. 2013 Oct;65(10):2713-23
pubmed: 23840006
Biomolecules. 2018 Oct 15;8(4):
pubmed: 30326650
J Immunol. 2001 Mar 1;166(5):3266-76
pubmed: 11207281
Lancet. 1966 Nov 19;2(7473):1087-93
pubmed: 4162525
Clin Rheumatol. 2006 May;25(3):341-6
pubmed: 16249826
N Engl J Med. 1991 May 23;324(21):1464-70
pubmed: 2023606
J Cell Biol. 1976 Nov;71(2):666-9
pubmed: 11223
Bioconjug Chem. 2009 Dec;20(12):2286-92
pubmed: 19916518
N Engl J Med. 1993 Nov 11;329(20):1463-6
pubmed: 8413457
Vaccine. 2003 Jul 28;21(24):3362-4
pubmed: 12850340
Nature. 1966 Jun 4;210(5040):1070-1
pubmed: 5950290
Nat Rev Immunol. 2003 Apr;3(4):331-41
pubmed: 12669023
Methods Mol Biol. 2016;1438:115-22
pubmed: 27150087
J Exp Med. 1992 Feb 1;175(2):397-404
pubmed: 1370683
J Clin Invest. 1995 May;95(5):2397-402
pubmed: 7738203
Eur J Immunol. 1988 Feb;18(2):313-6
pubmed: 3350037
Thromb Haemost. 2002 Dec;88(6):898-9
pubmed: 12529736
Rejuvenation Res. 2010 Apr-Jun;13(2-3):229-36
pubmed: 20345279
J Clin Invest. 1966 Nov;45(11):1826-38
pubmed: 4162738
J Exp Med. 1981 Apr 1;153(4):1004-8
pubmed: 7019374
Eur J Immunol. 1999 Mar;29(3):733-44
pubmed: 10092075
Nat Biotechnol. 1997 Jul;15(7):637-40
pubmed: 9219265
J Cell Sci. 2002 Jun 1;115(Pt 11):2389-97
pubmed: 12006623
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4217-20
pubmed: 3159020
Structure. 1998 Jan 15;6(1):63-73
pubmed: 9493268
J Exp Med. 2003 Feb 3;197(3):315-22
pubmed: 12566415
Reprod Toxicol. 2016 Sep;64:180-90
pubmed: 27282947
Eur J Immunol. 1976 Jul;6(7):497-501
pubmed: 62670
Sci Adv. 2019 Dec 18;5(12):eaax9586
pubmed: 31897428
Histochem Cell Biol. 2002 Feb;117(2):187-93
pubmed: 11935295
Blood. 2013 Aug 22;122(8):1419-27
pubmed: 23847198
Proc Natl Acad Sci U S A. 1996 May 28;93(11):5512-6
pubmed: 8643606
Nat Rev Immunol. 2007 Mar;7(3):213-9
pubmed: 17318232
Cell. 2019 Jun 27;178(1):190-201.e11
pubmed: 31204101
J Biochem. 1980 Feb;87(2):393-7
pubmed: 7358644
Clin Sci Mol Med. 1977 Apr;52(4):383-94
pubmed: 862334
Eur J Immunol. 1996 Mar;26(3):690-6
pubmed: 8605939
N Engl J Med. 2002 Sep 19;347(12):869-77
pubmed: 12239255
J Immunol. 2006 May 15;176(10):6277-85
pubmed: 16670339
Lancet Infect Dis. 2016 Sep;16(9):1026-1035
pubmed: 27261067
Rev Med Interne. 2015 Mar;36(3):159-66
pubmed: 25240481
Blood. 2006 Nov 15;108(10):3573-9
pubmed: 16849638
Clin Biochem. 2010 Mar;43(4-5):367-72
pubmed: 20006594
Biochim Biophys Acta. 2013 Dec;1830(12):5535-44
pubmed: 23528895
Haematologica. 2019 Feb;104(2):236-244
pubmed: 30514798
Obstet Gynecol. 2008 Jul;112(1):164-76
pubmed: 18591322
Biochemistry. 2006 Apr 18;45(15):4983-90
pubmed: 16605266
Dev Cell. 2005 Mar;8(3):377-87
pubmed: 15737933
Proc R Soc Lond B Biol Sci. 1955 Mar 15;143(912):408-13
pubmed: 14371615
Mol Biol Cell. 2005 Apr;16(4):2028-38
pubmed: 15689494
Cell Tissue Res. 1990 Aug;261(2):383-8
pubmed: 2401009
Cancer Immunol Immunother. 2007 Mar;56(3):303-317
pubmed: 16738850
Allergy. 2000 Aug;55(8):688-97
pubmed: 10955693
Clin Exp Allergy. 2012 Dec;42(12):1791-800
pubmed: 23181795
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32
pubmed: 21628593
Immunology. 1997 Sep;92(1):69-74
pubmed: 9370926
J Immunol. 2007 Oct 1;179(7):4580-8
pubmed: 17878355
Am J Reprod Immunol. 1994 Aug;32(1):8-14
pubmed: 7945815
Clin Obstet Gynecol. 1993 Mar;36(1):24-32
pubmed: 8435945
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2788-93
pubmed: 19188594
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8375-80
pubmed: 18544647
J Clin Invest. 1972 Nov;51(11):2916-27
pubmed: 5080417
Prog Allergy. 1969;13:1-110
pubmed: 4186070
Hum Immunol. 2001 Feb;62(2):93-105
pubmed: 11182218
J Am Coll Cardiol. 1998 Jun;31(7):1658-66
pubmed: 9626848
Trends Immunol. 2015 Nov;36(11):684-696
pubmed: 26497259
J Exp Med. 2018 Jan 2;215(1):91-113
pubmed: 29158374
Dig Dis Sci. 1997 May;42(5):1062-9
pubmed: 9149063
Behav Sci (Basel). 2019 Apr 29;9(5):
pubmed: 31035713
Clin Diagn Lab Immunol. 1999 Nov;6(6):868-71
pubmed: 10548578
Biochim Biophys Acta. 2013 Dec;1830(12):5526-34
pubmed: 23639804
N Engl J Med. 2001 Sep 6;345(10):747-55
pubmed: 11547745
J Immunol. 1984 Sep;133(3):1197-201
pubmed: 6430996
J Biol Chem. 2013 Aug 16;288(33):24277-85
pubmed: 23818524
Cytogenet Cell Genet. 1996;73(1-2):97-8
pubmed: 8646894
J Exp Med. 1965 Mar 1;121:323-38
pubmed: 14271318
Exp Hematol. 2005 Sep;33(9):1021-8
pubmed: 16140150
Eur J Immunol. 1977 Sep;7(9):591-7
pubmed: 411678
MAbs. 2019 Jul;11(5):848-860
pubmed: 30964743
Biochemistry. 1993 Aug 24;32(33):8654-60
pubmed: 8357807
J Exp Med. 2006 Mar 20;203(3):519-27
pubmed: 16533884
Springer Semin Immunopathol. 2006 Dec;28(4):397-403
pubmed: 17051393
J Cell Biol. 1984 Jul;99(1 Pt 2):159s-164s
pubmed: 6235233
MAbs. 2013 Jul-Aug;5(4):576-86
pubmed: 23765230