Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.

Administration, Intravenous Administration, Oral Animals Area Under Curve Biological Availability Biomarkers / analysis Coproporphyrins / analysis Cyclosporine / administration & dosage Drug Evaluation, Preclinical / methods Drug Interactions Half-Life Intestinal Absorption Kidney / drug effects Liver / drug effects Liver-Specific Organic Anion Transporter 1 / antagonists & inhibitors Macaca fascicularis Male Mice Rifampin / administration & dosage Tissue Distribution

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
08 2020
Historique:
received: 28 01 2020
accepted: 19 05 2020
pubmed: 3 6 2020
medline: 14 9 2021
entrez: 3 6 2020
Statut: ppublish

Résumé

Despite a recent expansion in the recognition of the potential utility of coproporphyrin (CP) as an endogenous biomarker of organic anion-transporting polypeptide (OATP) 1B activity, there have been few detailed studies of CP's pharmacokinetic behavior and an overall poor understanding of its pharmacokinetic fate from tissues and excretion. Here, we describe the pharmacokinetics of octadeuterium-labeled coproporphyrin I (CPI-d8) in cynomolgus monkeys following oral and intravenous administration. CPI-d8 has a half-life and bioavailability of 7.6 hours and 3.2%, respectively. Cynomolgus monkeys received oral cyclosporin A (CsA) at 4, 20, and 100 mg/kg which yielded maximum blood concentrations (

Identifiants

DOI: 10.1124/dmd.120.090670 PMID: 32482623
pubmed: 32482623
pii: dmd.120.090670
doi: 10.1124/dmd.120.090670
doi:

Substances chimiques

Biomarkers 0
Coproporphyrins 0
Liver-Specific Organic Anion Transporter 1 0
coproporphyrin III 14643-66-4
coproporphyrin I 531-14-6
Cyclosporine 83HN0GTJ6D
Rifampin VJT6J7R4TR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-734

Informations de copyright

Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Xiaomei Gu (X)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

Lifei Wang (L)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

Jinping Gan (J)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

R Marcus Fancher (RM)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

Yuan Tian (Y)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

Yang Hong (Y)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey hong.shen1@bms.com.

Yurong Lai (Y)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

Michael Sinz (M)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey.

Hong Shen (H)

Departments of Metabolism and Pharmacokinetics (X.G., L.W., J.G., R.M.F., Y.L., M.S., H.S.) and Radiochemistry (Y.T., Y.H.), Bristol Myers Squibb Company, Princeton, New Jersey hong.shen1@bms.com.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie intraveineuse › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Eucaryotes › Animaux › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Coproporphyrines › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Cyclosporines › Ciclosporine › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Phénomènes physiques › Temps › Période › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Absorption gastro-intestinale › Absorption intestinale › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Système digestif › Foie › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Polypeptide C de transport d'anions organiques › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Lactames macrocycliques › Rifamycine › Rifampicine › Absorption and Disposition of Coproporphyrin I...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Absorption and Disposition of Coproporphyrin I...