Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.
Abdominal Wall
/ diagnostic imaging
Adiposity
Aged
Cohort Studies
Female
Humans
Lung Diseases
/ mortality
Lung Transplantation
Male
Middle Aged
Muscle, Skeletal
/ diagnostic imaging
Risk Assessment
Survival Rate
Thigh
/ diagnostic imaging
Tomography, X-Ray Computed
Treatment Outcome
Waiting Lists
/ mortality
Walk Test
clinical epidemiology
imaging/CT MRI etc
lung transplantation
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
16
12
2019
revised:
25
04
2020
accepted:
07
05
2020
pubmed:
3
6
2020
medline:
23
12
2020
entrez:
3
6
2020
Statut:
ppublish
Résumé
CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification.
Identifiants
pubmed: 32482837
pii: thoraxjnl-2019-214461
doi: 10.1136/thoraxjnl-2019-214461
pmc: PMC7888552
mid: NIHMS1658896
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
801-804Subventions
Organisme : CSRD VA
ID : IK2 CX001034
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL115354
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114626
Pays : United States
Organisme : CSRD VA
ID : I01 CX002011
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL143645
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL131937
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134851
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087115
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL105323
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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