Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders.
Adult
Alcohol Drinking
/ blood
Alcoholism
/ blood
Cotinine
/ metabolism
Female
Humans
Male
Melatonin
/ blood
Middle Aged
Orexins
/ blood
Oxytocin
/ blood
Saliva
/ chemistry
Smoking
/ blood
Substance P
/ blood
Tobacco Use Disorder
/ blood
alpha-MSH
/ blood
beta-Endorphin
/ blood
gamma-Glutamyltransferase
/ blood
Journal
The American journal on addictions
ISSN: 1521-0391
Titre abrégé: Am J Addict
Pays: England
ID NLM: 9208821
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
11
02
2020
revised:
23
04
2020
accepted:
09
05
2020
pubmed:
4
6
2020
medline:
29
6
2021
entrez:
4
6
2020
Statut:
ppublish
Résumé
In this secondary analysis of a pilot clinical trial with individuals with alcohol and nicotine use disorders, we investigate the relationship between serum concentrations of oxytocin, β-endorphin, melatonin, α-melanocyte-stimulating hormone, substance P, and orexin, with objective biomarkers (salivary cotinine and serum γ-glutamyl transferase [GGT]) as well as with self-reported smoking and alcohol drinking. Biomarkers for a total of N = 19 participants were analyzed using multiplexed, competitive format immune-assay (peptides) and enzyme competitive immunoassay (saliva). A regression analysis using Pearson's correlation coefficient was utilized to determine correlations. We controlled for multiple comparisons, checked for collinearities, and ran two-sided statistical tests. We found significant positive correlations for cotinine and oxytocin (P = .002), β-endorphin (P = .008), and orexin (P < .001), but not for either GGT or self-reported smoking or alcohol drinking. These preliminary results suggest a relationship between cotinine and oxytocin, β-endorphin, and orexin, which opens up new potential hypotheses on the potential role of these endocrine pathways in tobacco smokers. (Am J Addict 2021;30:88-91).
Sections du résumé
BACKGROUND AND OBJECTIVES
In this secondary analysis of a pilot clinical trial with individuals with alcohol and nicotine use disorders, we investigate the relationship between serum concentrations of oxytocin, β-endorphin, melatonin, α-melanocyte-stimulating hormone, substance P, and orexin, with objective biomarkers (salivary cotinine and serum γ-glutamyl transferase [GGT]) as well as with self-reported smoking and alcohol drinking.
METHODS
Biomarkers for a total of N = 19 participants were analyzed using multiplexed, competitive format immune-assay (peptides) and enzyme competitive immunoassay (saliva). A regression analysis using Pearson's correlation coefficient was utilized to determine correlations. We controlled for multiple comparisons, checked for collinearities, and ran two-sided statistical tests.
RESULTS
We found significant positive correlations for cotinine and oxytocin (P = .002), β-endorphin (P = .008), and orexin (P < .001), but not for either GGT or self-reported smoking or alcohol drinking.
CONCLUSION AND SCIENTIFIC SIGNIFICANCE
These preliminary results suggest a relationship between cotinine and oxytocin, β-endorphin, and orexin, which opens up new potential hypotheses on the potential role of these endocrine pathways in tobacco smokers. (Am J Addict 2021;30:88-91).
Identifiants
pubmed: 32488890
doi: 10.1111/ajad.13064
pmc: PMC7944578
mid: NIHMS1671307
doi:
Substances chimiques
Orexins
0
Substance P
33507-63-0
Oxytocin
50-56-6
alpha-MSH
581-05-5
beta-Endorphin
60617-12-1
gamma-Glutamyltransferase
EC 2.3.2.2
Melatonin
JL5DK93RCL
Cotinine
K5161X06LL
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-91Subventions
Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases
ID : R01AI127699
Organisme : NIAAA NIH HHS
ID : R01 AA026589
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA023867
Pays : United States
Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases
ID : R01AI110699
Organisme : NIAID NIH HHS
ID : R21 AI131047
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA027614
Pays : United States
Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases
ID : R01HD092301
Organisme : NIAAA NIH HHS
ID : R01 AA027760
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM130414
Pays : United States
Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases
ID : R21AI131047
Organisme : NIAID NIH HHS
ID : R01 AI110699
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127699
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AA000218
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007459
Pays : United States
Organisme : NIAAA NIH HHS
ID : R03 AA020169
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD092301
Pays : United States
Informations de copyright
© 2020 American Academy of Addiction Psychiatry.
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