Effects of resveratrol on autophagy and the expression of inflammasomes in a placental trophoblast oxidative stress model.
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Autophagy
/ drug effects
Caspase 1
/ metabolism
Catalase
/ metabolism
Cell Line
Cell Survival
/ drug effects
Female
Fluorescent Dyes
/ chemistry
Humans
Hydrogen Peroxide
/ toxicity
Inflammasomes
/ metabolism
Interleukin-1beta
/ metabolism
L-Lactate Dehydrogenase
/ metabolism
Malondialdehyde
/ metabolism
Models, Biological
Oxidative Stress
/ drug effects
Pregnancy
Reactive Oxygen Species
/ metabolism
Resveratrol
/ pharmacology
Superoxide Dismutase
/ metabolism
Trophoblasts
/ drug effects
Autophagy
HTR-8/SVneo
Inflammasome
Oxidative stress
Resveratrol
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
28
04
2020
revised:
21
05
2020
accepted:
29
05
2020
pubmed:
5
6
2020
medline:
1
9
2020
entrez:
5
6
2020
Statut:
ppublish
Résumé
We aim to investigate whether there is activation of NLRP1 and autophagy in trophoblast oxidative stress model. Resveratrol was taken to clarify its role in oxidative damage of placental trophoblasts. H 300 μmol/L H Trophoblast oxidative damage model can be established under 300 μmol/L H H
Identifiants
pubmed: 32497634
pii: S0024-3205(20)30640-8
doi: 10.1016/j.lfs.2020.117890
pii:
doi:
Substances chimiques
Antioxidants
0
Fluorescent Dyes
0
IL1B protein, human
0
Inflammasomes
0
Interleukin-1beta
0
Reactive Oxygen Species
0
Malondialdehyde
4Y8F71G49Q
Hydrogen Peroxide
BBX060AN9V
L-Lactate Dehydrogenase
EC 1.1.1.27
Catalase
EC 1.11.1.6
Superoxide Dismutase
EC 1.15.1.1
Caspase 1
EC 3.4.22.36
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117890Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest There are no conflicts of interest.