Mitochondrial ATP-sensitive potassium channel, MitoKATP, ameliorates mitochondrial dynamic disturbance induced by temporal lobe epilepsy.
5-HD
Mitochondrial fission
Mitochondrial fusion
Temporal lobe epilepsy
mitoKATP
Journal
Journal of chemical neuroanatomy
ISSN: 1873-6300
Titre abrégé: J Chem Neuroanat
Pays: Netherlands
ID NLM: 8902615
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
16
02
2020
revised:
04
05
2020
accepted:
26
05
2020
pubmed:
5
6
2020
medline:
2
10
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
Temporal lobe epilepsy leads to a disturbance in the function and dynamic of the mitochondria. The mitoKATP channel is an important factor in controlling mitochondrial function. In this study, the protective role of mitoKATP was studied in temporal lobe epilepsy through the regulation of mitochondrial dynamic proteins. After induction of epilepsy, 5-HD (the inhibitor of mitoKATP) was administered daily for either 24 or 72 h. The results revealed an imbalance in dynamic proteins after epilepsy, specifically in the first 72 h. The disturbance in the mitochondrial dynamic worsened after blocking mitoKATP. In conclusion, mitoKATP has an important role in balancing mitochondrial dynamic proteins in epilepsy.
Identifiants
pubmed: 32497687
pii: S0891-0618(20)30077-6
doi: 10.1016/j.jchemneu.2020.101808
pii:
doi:
Substances chimiques
KATP Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101808Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.